Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching
Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching
复制标题
DOI：
10.1016/j.neuron.2020.01.015
复制
发表时间：
2020-04-08
期刊：
影响因子：
16.2
通讯作者：
Csicsvari, Jozsef
中科院分区：
文献类型：
--
作者：
Kaefer, Karola;Nardin, Michele;Csicsvari, Jozsef
在清醒的静止阶段，有时间组织的重新激活的经验被认为是计划和评估等认知过程的基础。虽然海马体已经很好地建立了轨迹重播，但内侧前额叶皮质(MPFC)是否能重新激活清醒状态下的顺序行为体验以支持任务执行尚不清楚。我们同时记录了在正迷宫上执行依赖于mPFC的规则转换任务的大鼠的海马区和mPFC主神经元。我们发现，mPFC神经元活动编码了开始和目标之间的相对位置。在清醒不动期间，mPFC重播这些广义位置的时间组织序列，类似于整个空间轨迹。MPFC轨迹重播的发生与规则转换绩效呈正相关。然而，海马和mPFC轨迹重放是独立发生的，表明不同的功能。这些结果表明，mPFC能够再现代表广义位置的有序活动模式，并提示mPFC再现可能在灵活行为中发挥作用。
Temporally organized reactivation of experiences during awake immobility periods is thought to underlie cognitive processes like planning and evaluation. While replay of trajectories is well established for the hippocampus, it is unclear whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral experiences in the awake state to support task execution. We simultaneously recorded from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent rule-switching task on a plus maze. We found that mPFC neuronal activity encoded relative positions between the start and goal. During awake immobility periods, the mPFC replayed temporally organized sequences of these generalized positions, resembling entire spatial trajectories. The occurrence of mPFC trajectory replay positively correlated with rule-switching performance. However, hippocampal and mPFC trajectory replay occurred independently, indicating different functions. These results demonstrate that the mPFC can replay ordered activity patterns representing generalized locations and suggest that mPFC replay might have a role in flexible behavior.