Chromosomal disorders and autism
Chromosomal disorders and autism
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DOI：
10.1023/a:1026004505764
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发表时间：
1998-10-01
影响因子：
3.9
通讯作者：
Gillberg, C
中科院分区：
文献类型：
--
作者：
Gillberg, C
许多自闭症病例似乎是由几个异常基因协同作用引起的。本文综述了自闭症染色体畸变的相关文献，以期发现自闭症的潜在基因标记。大多数染色体都与自闭症的发生有关。然而，15号染色体长臂畸变和性染色体的数量和结构异常是最常见的报道。这些染色体似乎在寻找候选基因方面具有特殊的前景。
Many cases of autism appear to be caused by several abnormal genes acting in concert. The literature on chromosomal aberrations in autism is reviewed, with a view to finding potential gene markers for the neuropsychiatric disorder. Most of the chromosomes have been implicated in the genesis of autism. However, aberrations on the long arm of Chromosome 15 and numerical and structural abnormalities of the sex chromosomes have been most frequently reported. These chromosomes appear to hold particular promise in the search for candidate genes.