The challenge of malaria eradication in the twenty-first century: Research linked to operations is the key
The challenge of malaria eradication in the twenty-first century: Research linked to operations is the key
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DOI：
10.1016/j.vaccine.2011.12.003
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发表时间：
2011-12-30
期刊：
影响因子：
5.5
通讯作者：
Brandling-Bennett, A. David
中科院分区：
文献类型：
--
作者：
Breman, Joel G.;Brandling-Bennett, A. David
在过去十年中，对疟疾控制、根除和研究的兴趣和支持大大增加。这是因为认识到疟疾给流行人群带来的巨大医疗、社会和经济负担。最近在药物开发（青蒿素类复方疗法）、预防性干预措施（长效驱虫蚊帐）、改进的诊断（快速诊断检测）和社区动员方面取得的突破，导致部署了新的抗疟工具。全球抗击艾滋病、结核病和疟疾基金、美国总统疟疾倡议和其他捐助者支持的国家项目已大幅降低疟疾发病率和死亡率。比尔·盖茨和梅林达·盖茨夫妇大力推动根除疟疾工作，支持制定关键研究战略，并直接资助创新研究项目，包括疟疾疫苗和药物研发，以减少疾病和传播。将研究与实地行动联系起来是一项成功消灭天花的战略，也是消灭疟疾所必需的。爱思唯尔有限公司出版
Interest and support for malaria control, eradication, and research has increased greatly over the past decade. This has resulted from appreciation of the huge medical, social, and economic burden that malaria exacts from endemic populations. Recent breakthroughs in drug development (artemisinin-based combination treatments), preventive interventions (long-lasting, insecticide-treated bed nets), improved diagnosis (rapid diagnostic tests), and community mobilization have resulted in deployment of new antimalarial tools. National programs supported by the Global Fund to Fight AIDS, Tuberculosis and Malaria, the U.S. President's Malaria Initiative, and other donors have resulted in substantial reductions in malaria morbidity and mortality. Bill and Melinda Gates have given great impetus to eradication with support for the development of key research strategies and direct funding of innovative research projects, including malaria vaccine and drug discovery, that could decrease disease and transmission. Linking research to field operations is a strategy that succeeded for smallpox eradication and will be required for the demise of malaria. Published by Elsevier Ltd.