Recent Development in Therapeutic Cardiac Patches.
Recent Development in Therapeutic Cardiac Patches.
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DOI：
10.3389/fcvm.2020.610364
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发表时间：
2020
影响因子：
3.6
通讯作者：
Cheng K
中科院分区：
文献类型：
--
作者：
Mei X;Cheng K
在过去的几十年里，心脏病仍然是世界范围内死亡的主要原因。在成年哺乳动物心脏中，由于心脏再生能力差，受损的心肌细胞会被无收缩性的纤维化疤痕组织所取代，从而导致心力衰竭。组织工程的发展为心脏再生带来了新的医学创新。心脏贴片在临床上具有修复心脏功能的潜力，是目前最突出的技术之一。心脏贴片由两部分组成：治疗成分和基质支架，它的制造需要先进的生物活性分子和生物材料。在这篇综述中，我们将介绍最先进的心脏贴片，并分析它们的组成细节。治疗成分将从细胞来源到生物活性分子进行讨论。同时，将重点介绍近期获得支架生物材料的进展，包括合成材料和天然材料。此外，我们还关注了制造临床应用心脏贴片的挑战和潜在策略。
For the past decades, heart diseases remain the leading cause of death worldwide. In the adult mammalian heart, damaged cardiomyocytes will be replaced by non-contractile fibrotic scar tissues due to the poor regenerative ability of heart, causing heart failure subsequently. The development of tissue engineering has launched a new medical innovation for heart regeneration. As one of the most outstanding technology, cardiac patches hold the potential to restore cardiac function clinically. Consisted of two components: therapeutic ingredients and substrate scaffolds, the fabrication of cardiac patches requires both advanced bioactive molecules and biomaterials. In this review, we will present the most state-of-the-art cardiac patches and analysis their compositional details. The therapeutic ingredients will be discussed from cell sources to bioactive molecules. In the meanwhile, the recent advances to obtain scaffold biomaterials will be highlighted, including synthetic and natural materials. Also, we have focused on the challenges and potential strategies to fabricate clinically applicable cardiac patches.