Impaired pulmonary function after treatment for tuberculosis: the end of the disease?
Impaired pulmonary function after treatment for tuberculosis: the end of the disease?
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DOI：
10.1590/s1806-37562016000000053
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发表时间：
2017-01
期刊：
影响因子：
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通讯作者：
Ots ON
中科院分区：
文献类型：
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作者：
Chushkin MI;Ots ON
目的探讨肺结核患者肺功能异常的发生率及影响肺功能的因素。 共有214名连续患者（132名男性和82名女性;年龄20 - 82岁）接受肺结核治疗并在当地药房随访，在治疗后至少一年进行肺功能测定和体积描记。 在评价的214例患者中，102例（47.7%）存在肺功能损害。最常见的功能改变是阻塞性肺疾病（34.6%）。在214例患者中，60例（28.0%）显示肺功能降低（FEV1低于正常下限）。肺功能下降的危险因素是过去曾有培养阳性的肺结核，年龄超过50岁，有复发性结核病，并具有较低的教育水平。 近一半的结核病患者会发展为肺功能受损。这强调了在治疗结束后需要进行肺功能测试。
To evaluate the prevalence of pulmonary function abnormalities and to investigate the factors affecting lung function in patients treated for pulmonary tuberculosis. A total of 214 consecutive patients (132 men and 82 women; 20-82 years of age), treated for pulmonary tuberculosis and followed at a local dispensary, underwent spirometry and plethysmography at least one year after treatment. Pulmonary impairment was present in 102 (47.7%) of the 214 patients evaluated. The most common functional alteration was obstructive lung disease (seen in 34.6%). Of the 214 patients, 60 (28.0%) showed reduced pulmonary function (FEV1 below the lower limit of normal). Risk factors for reduced pulmonary function were having had culture-positive pulmonary tuberculosis in the past, being over 50 years of age, having recurrent tuberculosis, and having a lower level of education. Nearly half of all tuberculosis patients evolve to impaired pulmonary function. That underscores the need for pulmonary function testing after the end of treatment.