Normal dose of pilsicainide showed marked negative inotropic effects in a patient who had no underlying heart disease.
Normal dose of pilsicainide showed marked negative inotropic effects in a patient who had no underlying heart disease.
复制标题
正常剂量的匹西卡尼对没有潜在心脏病的患者显示出明显的负性肌力作用。
DOI：
10.1016/j.joa.2013.04.004
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kadokami T.
中科院分区：
文献类型：
--
作者：
Yoshida M;Ando S;Chishaki A;Makita N;Hasegawa Y;Narita S;Momii H;Kadokami T.
我们报告了一位健康的64岁女性，在服用匹西奈治疗阵发性心房颤动后出现了心肺骤停。她曾有一次阵发性心房颤动，但入院前无肝功能、肾功能不全或超声心动图异常。入院当天和次日，静脉给予匹西卡因50 mg，超过10分钟（总计100 mg）。第二次注射后不久，患者出现明显的心动过缓和低血压，最终进入无脉电活动状态。立即开始心肺复苏。虽然临时起搏器的应用恢复了她的心率，超声心动图显示没有左心室收缩。我们开始了经皮心肺支持（pps）和主动脉内球囊泵送（IABP）。发病3天后，患者心脏收缩逐渐恢复，完全恢复正常。病人出院时可以走动。
We report the case of an otherwise healthy 64‐year‐old female who developed cardiopulmonary arrest after the administration of pilsicainide for treatment of paroxysmal atrial fibrillation. She had had an episode of paroxysmal atrial fibrillation, but no liver dysfunction, renal dysfunction, or echocardiographic abnormality before her admission. On the day of admission and the following day, 50 mg of pilsicainide was administered intravenously over 10 min (total 100 mg). Shortly after the second injection, she developed marked bradycardia and hypotension and eventually fell into a state of pulseless electrical activity. Immediate cardiopulmonary resuscitation was started. Although application of a temporary pacemaker restored her heart rate, echocardiography revealed no left ventricular contraction. We started percutaneous cardiopulmonary support (PCPS) and intra‐aortic balloon pumping (IABP). Her cardiac contraction gradually recovered and returned to completely normality 3 days after the onset. The patient was discharged in an ambulatory condition.