Can the retinal ganglion cell layer (GCL) volume be a new marker to detect neurodegeneration in bipolar disorder?
Can the retinal ganglion cell layer (GCL) volume be a new marker to detect neurodegeneration in bipolar disorder?
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DOI：
10.1016/j.comppsych.2016.02.005
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发表时间：
2016-05-01
影响因子：
7.3
通讯作者：
Ozen, Murat Eren
中科院分区：
文献类型：
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作者：
Kalenderoglu, Aysun;Sevgi-Karadag, Ayse;Ozen, Murat Eren
目的：本研究的目的是使用光学相干断层扫描技术比较双相情感障碍患者和对照的神经节细胞层 (GCL) 体积和视网膜神经纤维层 (RNFL) 厚度，以证明双相情感障碍的神经变性。 方法：本研究涉及由阿德亚曼大学医学院精神病学系跟踪的 43 名正常双相情感障碍患者和 43 名健康志愿者作为对照。对两组进行光学相干断层扫描（OCT）测量。通过光谱 OCT 设备自动测量和记录 RNFL 厚度和 GCL 体积。结果：除了失业状况（患者组的失业率明显较高）外，各组之间没有发现社会人口统计学差异。在所有测量区域，患者的 RNFL 厚度均低于对照组，并且这种下降对于整体 RNFL 测量具有统计学意义。患者组的 GCL 体积也显着降低。疾病参数，如病程、YMRS评分、CGI评分、住院次数和GCL体积之间存在显着的负相关。讨论：这些发现表明神经变性发生在双相情感障碍的病程中。这种变性可以通过早期 GCL 的减少来证明，并且随着疾病的进展，可以观察到其他视网膜层（例如 RNFL 和 IPL）的受累。 (C) 2016 Elsevier Inc. 保留所有权利。
Purpose: The aim of this study was to compare the ganglion cell layer (GCL) volume and retinal nerve fiber layer (RNFL) thickness in bipolar patients and controls using optic coherence tomography to demonstrate neurodegeneration in bipolar disorder.Methods: This study involved 43 euthymic bipolar I patients who were being followed by the Psychiatry Department of Adiyaman University Medical School and 43 healthy volunteers as controls. Optic coherence tomography (OCT) measurements were performed for both groups. The RNFL thickness and GCL volumes were measured and recorded automatically by a spectral OCT device.Findings: No differences in sociodemographics were detected between groups, except for unemployment status, which was significantly higher in the patient group. The RNFL thickness was lower in patients compared with controls at all measured regions, and this decrease was statistically significant for the global RNFL measurement. The GCL volume was also significantly lower in the patient group. There was a significant negative correlation between the disease parameters, such as the disease duration, YMRS score, CGI score, and number of hospitalizations, and GCL volume.Discussion: These findings suggest that neurodegeneration occurs during the course of bipolar disorder. This degeneration may be demonstrated by decreased GCL at early stages, and as the disease progresses, involvement of other retinal layers, such as the RNFL and IPL, may be observed. (C) 2016 Elsevier Inc. All rights reserved.