Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features.
Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features.
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DOI：
10.1016/j.jbiomech.2021.110600
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发表时间：
2021-07
影响因子：
2.4
通讯作者：
E. Maghami;Timothy O. Josephson;Jason P. Moore;T. Rezaee;T. Freeman;L. Karim;A. Najafi
中科院分区：
文献类型：
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作者：
E. Maghami;Timothy O. Josephson;Jason P. Moore;T. Rezaee;T. Freeman;L. Karim;A. Najafi
糖尿病与人体骨折风险增加有关，尤其是在老年人群中。在本研究中，我们调查如何模拟晚期糖基化终产物（AGEs）和材料的异质性影响人类皮质骨裂纹扩展轨迹。我们使用相场断裂框架的2D模型的皮质微观结构从人类胫骨分析裂纹扩展。AGEs水平的增加导致更高的裂纹形成速率。模拟还表明，断裂性质之间的不匹配（例如，临界能量释放率）可以改变屈服后的行为。结果表明，如果骨水泥线的临界能量释放速率低于骨单位和周围间隙基质的临界能量释放速率，则骨水泥线可以阻止裂纹的产生。此外，增韧机制如裂纹合并和分支的活化取决于骨微结构形态（即，骨单位几何参数、骨管和骨陷窝孔隙度）。总之，目前的研究结果表明，材料的微观结构特征的异质性和裂纹-微观结构的相互作用可以发挥重要的作用，骨脆性。
Diabetes is associated with increased fracture risk in human bone, especially in the elderly population. In the present study, we investigate how simulated advanced glycation end-products (AGEs) and materials heterogeneity affect crack growth trajectory in human cortical bone. We used a phase field fracture framework on 2D models of cortical microstructure created from human tibias to analyze crack propagation. The increased AGEs level results in a higher rate of crack formation. The simulations also indicate that the mismatch between the fracture properties (e.g., critical energy release rate) of osteons and interstitial tissue can alter the post-yielding behavior. The results show that if the critical energy release rate of cement lines is lower than that of osteons and the surrounding interstitial matrix, cracks can be arrested by cement lines. Additionally, activation of toughening mechanisms such as crack merging and branching depends on bone microstructural morphology (i.e., osteons geometrical parameters, canals, and lacunae porosities). In conclusion, the present findings suggest that materials heterogeneity of microstructural features and the crack-microstructure interactions can play important roles in bone fragility.