A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1
A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1
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DOI：
10.1002/chem.201300696
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发表时间：
2013-06-01
影响因子：
4.3
通讯作者：
Ley, Steven V.
中科院分区：
文献类型：
--
作者：
Battilocchio, Claudio;Deadman, Benjamin J.;Ley, Steven V.
在这里，我们报道了神经降压素受体-1拮抗剂Meclinerant(SR48692，1)的传统批量模式合成与其机器辅助流动化学替代品的直接比较。通过使用这些使能工具，结合固体支撑试剂和清除剂，观察到了许多工艺优势。然而，必须注意不要将这些技术转化为昂贵的解决方案来解决不存在的问题。
Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.