Accelerated hypertension associated with lupus anticoagulant and false-positive VDRL in systemic lupus erythematosus.
Accelerated hypertension associated with lupus anticoagulant and false-positive VDRL in systemic lupus erythematosus.
复制标题
系统性红斑狼疮中与狼疮抗凝剂和假阳性 VDRL 相关的加速高血压。
DOI：
10.1002/art.1780290121
复制
发表时间：
1986
影响因子：
--
通讯作者：
G. Le Menn
中科院分区：
文献类型：
--
作者：
J. Jouquan;Y. Pennec;D. Mottier;P. Youinou;J. Clèdes;J. Leroy;G. Le Menn
我们饶有兴趣地阅读了Pappas等人的报告（1）和Hughes等人随后的评论（2）。我们观察到一个14岁的女孩提到深静脉血栓形成的右腿在1979年7月。梅毒的VDRL测试给出了假阳性结果。检测到具有抗凝血酶原酶活性的循环抗凝剂。既没有抗核抗体，也没有红斑狼疮细胞。1979年12月，根据非结合性高胆红素血症和低血清结合珠蛋白水平诊断为溶血性贫血。Coombs试验结果为阴性。1981年10月，患者因全身性癫痫发作再次入院。入院时，出现头痛、虚弱和昏迷样意识丧失。体格检查显示右脚踝和两个手腕的少关节炎，一个vespertilio样的肿胀性水肿，耳朵发炎，手掌和脚底有青斑样的皮肤病变。血压为2101120 mm Hg。检眼镜检查结果正常，但计算机断层扫描显示脑水肿。她的血细胞计数值正常;红细胞沉降率为92 mdhour（Westergren），血清纤维蛋白原值为9 gml。采用Farr技术测定抗核抗体为45单位/ml（正常值< 25单位/ml）。
We read the report by Pappas et al (1) and the subsequent comments by Hughes et a1 (2) with much interest. We observed a 14-year-old girl referred for a deep vein thrombosis of the right leg in July 1979. A VDRL test for syphilis gave a false-positive result. Circulating anticoagulant with antiprothrombinase activity was detected. There were neither antinuclear antibodies nor lupus erythematosus cells present. In December 1979, hemolytic anemia was diagnosed on the basis of nonconjugated hyperbilirubihemia and a low serum haptoglobin level. Results of a Coombs’ test were negative.In October 1981, the patient was readmitted for generalized seizures. On admission, headache, weakness, and stupor-like unconsciousness were present. Physical ex-amination showed oligoarthritis of the right ankle and both wrists, a vespertilio-like erythematous edema, chondritis of the ears, and livedo-like skin lesions on her palms and the soles of her feet. Blood pressure was 2101120 mm Hg. Ophthalmoscopic findings were normal, but a computerized tomography scan revealed cerebral edema. Her blood cell count values were normal; erythrocyte sedimentation rate was 92 mdhour (Westergren) and serum fibrinogen value was 9 gmiliter. Antinuclear antibodies were 45 unitdm1 using the Farr technique (normal zyxwvutsrqponmlkjih< 25 units/ml).