Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
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DOI：
10.1161/circresaha.116.307971
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发表时间：
2016-07-08
影响因子：
20.1
通讯作者：
Fayad ZA
中科院分区：
文献类型：
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作者：
Dweck MR;Aikawa E;Newby DE;Tarkin JM;Rudd JH;Narula J;Fayad ZA
主要的焦点放在易损斑块的识别上，作为改善心肌梗死预测的一种手段。然而，这一策略最近受到质疑，因为大多数这些个别冠状动脉病变实际上并没有引起临床事件。因此，人们的注意力转移到可能提供更完整的动脉粥样硬化疾病过程的泛冠状动脉评估的替代成像方式上。这些指标包括疾病活动性标志物，有可能区分代谢不再活跃的稳定衰竭性疾病患者和活动性动脉粥样硬化患者，疾病进展更快，梗死风险增加。这篇综述将探讨新的分子成像方法如何提供这样的评估，重点关注炎症和微钙化活动，这些过程对冠状动脉粥样硬化的重要性，以及这些技术的优势和挑战。
Major focus has been placed on the identification of vulnerable plaques as a means of improving the prediction of myocardial infarction. However, this strategy has recently been questioned on the basis that the majority of these individual coronary lesions do not in fact go on to cause clinical events. Attention is, therefore, shifting to alternative imaging modalities that might provide a more complete pan-coronary assessment of the atherosclerotic disease process. These include markers of disease activity with the potential to discriminate between patients with stable burnt-out disease that is no longer metabolically active and those with active atheroma, faster disease progression, and increased risk of infarction. This review will examine how novel molecular imaging approaches can provide such assessments, focusing on inflammation and microcalcification activity, the importance of these processes to coronary atherosclerosis, and the advantages and challenges posed by these techniques.