Acute, whole-body microwave exposure and testicular function of rats.
Acute, whole-body microwave exposure and testicular function of rats.
复制标题
大鼠的急性全身微波暴露和睾丸功能。
DOI：
10.1002/bem.2250080106
复制
发表时间：
1987
影响因子：
1.9
通讯作者：
Johnson,L
中科院分区：
文献类型：
--
作者：
Lebovitz,RM;Johnson,L
雄性Sprague-道利大鼠暴露于连续波微波辐射（MWR，1.3 Ghz）8 h，平均比吸收剂量率为9 mW/g。MWR暴露和假照射在单向通电的圆柱形波导部分中进行，其中动物基本上不受限制。在这种情况下，MWR治疗可使直肠深部温度升高至4.5 °C。在给药后6.5、13、26和52天（对应于生精上皮的0.5、1、2和4个周期）采集动物进行分析。测定睾丸、附睾和精囊的净重;每个睾丸和每克睾丸的每日精子产量（DSP）;以及附睾精子数量。循环促卵泡激素（FSH）和促黄体生成素（LH）的水平通过处死时采集的血浆样本的放射免疫测定法得出。尽管明显的急性产热的MWR在9毫瓦/克，睾丸功能没有实质性的减少被发现。我们的结论是，在不受约束的大鼠，全身照射在9毫瓦/克，而足以引起明显的高热，是不是一个足够的条件破坏任何这些关键措施的睾丸功能。
Male Sprague‐Dawley rats were exposed for 8 h to continuous‐wave microwave radiation (MWR, 1.3 Ghz) at a mean specific absorbed dose rate of 9 mW/g. MWR exposure and sham‐irradiation took place in unidirectionally energized cylindrical waveguide sections, within which the animals were essentially unrestrained. The MWR treatment in this setting was determined to yield an elevation of deep rectal temperature to 4.5 °C. The animals were taken for analysis at 6.5, 13, 26, and 52 days following treatment, which corresponded to 0.5, 1, 2, and 4 cycles of the seminiferous epithelium. Net mass of testes, epididymides, and seminal vesicles; daily sperm production (DSP) per testis and per gram of testis; and the number of epididymal sperm were determined. The levels of circulating follicle‐stimulating hormone (FSH) and leutinizing hormone (LH) were derived via radioimmunoassay of plasma samples taken at the time of sacrifice. Despite the evident acute thermogenesis of the MWR at 9 mW/g, no substantial decrement in testicular function was found. We conclude that, in the unrestrained rat, whole body irradiation at 9 mW/g, while sufficient to induce evident hyperthermia, is not a sufficient condition for disruption of any of these key measures of testicular function.