Marked increase of CD5 + B cells in hyperthyroid Graves' disease.
Marked increase of CD5 + B cells in hyperthyroid Graves' disease.
复制标题
甲状腺功能亢进格雷夫斯病患者 CD5 B 细胞显着增加。
DOI：
10.1016/s0165-2478(97)00151-x
复制
发表时间：
1989
影响因子：
4.6
通讯作者：
K. Miyai
中科院分区：
文献类型：
--
作者：
Yoshinori Iwatani;Nobuyuki Amino;T. Kaneda;Kiyoshi Ichihara;H. Tamaki;J. Tachi;F. Matsuzuka;S. Fukata;Kanji Kuma;K. Miyai
我们检测了各种甲状腺疾病患者外周血中携带CD5细胞表面抗原（CD5+ B细胞）的B淋巴细胞的比例，这些细胞能够产生自身抗体。在未经治疗的甲状腺功能亢进Graves病患者中，CD5+ B细胞水平明显高于正常范围（0.5-7.7%）（>9.0%），尽管约10%的患者血清中未检测到促甲状腺激素（TSH）受体抗体（TRAb）。然而，由于桥本甲状腺炎或亚急性甲状腺炎加重而未治疗的破坏性甲状腺毒症患者的CD5+ B细胞水平正常。刺激型甲亢Graves病患者CD5+ B细胞水平与甲状腺激素、TRAb水平相关，均显著升高。然而，一旦甲状腺功能亢进被抗甲状腺药物控制，CD5+ B细胞减少，随后TRAb减少。我们的结论是，CD5+ B细胞的比例是有用的治疗指标和格雷夫斯病的诊断及其与破坏性甲状腺毒症的区分。
We examined the proportions of B lymphocytes bearing CD5 cell surface antigen (CD5+ B cells), which are capable of making autoantibodies, in peripheral blood from patients with various thyroid diseases. The level of CD5+ B cells was markedly increased (>9.0%) above the normal range (0.5-7.7%) in untreated, hyperthyroid patients with Graves' disease, although about 10% of the patients had no detectable serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb). However, the levels of CD5+ B cells were normal in untreated patients with destructive thyrotoxicosis due to aggravation of Hashimoto's thyroiditis or subacute thyroiditis. In patients with stimulated hyperthyroid Graves' disease the levels of CD5+ B cells were correlated with those of thyroid hormones and TRAb, all significantly increased. However, once hyperthyroidism was controlled by anti-thyroid drugs, CD5+ B cells were decreased, followed in turn by reduction of TRAb. We conclude that the proportion of CD5+ B cells is useful as a therapeutic index and for diagnosis of Graves' disease and its differentiation from destruction-induced thyrotoxicosis.