A Case‐Control Study of the Effectiveness of Cervical Cancer Screening in Osaka, Japan
A Case‐Control Study of the Effectiveness of Cervical Cancer Screening in Osaka, Japan
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日本大阪宫颈癌筛查有效性的病例对照研究
DOI：
10.1111/j.1349-7006.1988.tb01555.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
I. Fujimoto
中科院分区：
文献类型：
--
作者：
T. Sobue;Takaichiro Suzuki;S. Hashimoto;Nobuko Yokoi;I. Fujimoto
在日本大阪的鼻子小镇，自1965年以来，巴氏涂片进行了一项以人群为基础的宫颈癌筛查计划。为了评价筛查在降低浸润性宫颈癌死亡率和发病率方面的效果，进行了两种类型的病例对照研究。在第一项研究中，病例系列包括1965-1987年诊断时死于宫颈癌的所有80岁以下的妇女(N=15)。对于每个病例，从活着的居民中选择了10名对照，与出生年份相匹配。筛查与未筛查妇女死于宫颈癌的优势比(OR)为0.22(95%CI=0.03~1.95)。在第二项研究中，病例系列包括所有在同一时期(N=28)被诊断为在80岁以下被诊断为浸润性癌症的妇女。对于每个病例，从没有浸润性癌症的活着的居民中选择10名对照，按出生年份匹配，并根据他们是否在匹配病例诊断的年份进行筛查。筛查妇女与未筛查妇女患浸润性癌的OR值分别为0.41(95%CI=0.13~1.29)。根据这些结果，估计未经筛查的妇女中78%的宫颈癌死亡率和59%的浸润性宫颈癌发病率可以通过宫颈癌筛查来预防。
In the small town of Nose in Osaka, Japan, a population‐based screening program for cervical cancer by Papanicolaou smear has been conducted since 1965. In order to evaluate the effectiveness of screening in terms of the reduction of the mortality and the incidence of invasive cervical cancer, two types of case‐control studies were carried out. In the first study, the case series consisted of all women who died of cervical cancer under 80 years of age at the time of diagnosis in 1965‐1987 (N = 15). For each case, 10 controls were chosen from living residents, matched by year of birth. It showed that the odds ratio (OR) of dying of cervical cancer for screened versus non‐screened women was 0.22 (95%CI = 0.03‐1.95). In the second study, the case series consisted of all women who were diagnosed as having invasive cancer under 80 years of age at the time of diagnosis in the same period (N = 28). For each case, 10 controls were chosen from living residents without invasive cancer, matched by year of birth and according to whether or not they were screened at the year of the diagnosis of the matched case. It showed that the OR of getting invasive cancer for screened versus non‐screened women was 0,41 (95%CI = 0.13‐1.29). From these results, it was estimated that 78% of cervical cancer mortality and 59% of invasive cervical cancer incidence among non‐screened women could be prevented by cervical cancer screening.