A simple method for kinetic control of DNA-induced nanoparticle assembly
A simple method for kinetic control of DNA-induced nanoparticle assembly
复制标题
DOI：
10.1021/ja0654229
复制
发表时间：
2006-11-01
影响因子：
15
通讯作者：
Gang, Oleg
中科院分区：
文献类型：
--
作者：
Maye, Mathew M.;Nykypanchuk, Dmytro;Gang, Oleg
传感、纳米器件组装和基因传递等新兴应用需要对基于 DNA 的纳米系统的动力学行为进行调节。在这里，我们描述了一种广泛适用的方法，通过定制单链和部分刚性双链设计之间的 DNA 封端来控制 DNA 介导的纳米粒子自组装的动力学。增加的刚性促进了增强组装动力学的效果，增加的刚性降低了链熵，同时将关键的连接片段延伸远离已知它们协调的纳米颗粒界面。
A regulation of the kinetic behavior in DNA-based nanosystems is required for emerging applications in sensing, nanodevice assembling, and gene delivery. Here we describe a broadly applicable method for controlling the kinetics of DNA-mediated nanoparticle self-assembly by tailoring the DNA-capping between single-stranded and partially rigid double-stranded designs. An effect of enhanced assembly kinetics was facilitated by the added rigidity which reduced chain entropy while extending crucial linker segments away from the nanoparticle interface where they are known to coordinate.