BETA-AMYLOID PRECURSOR PROTEIN (BETA-APP) AS A MARKER FOR AXONAL INJURY AFTER HEAD-INJURY
BETA-AMYLOID PRECURSOR PROTEIN (BETA-APP) AS A MARKER FOR AXONAL INJURY AFTER HEAD-INJURY
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DOI：
10.1016/0304-3940(93)90398-5
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发表时间：
1993-10-01
影响因子：
2.5
通讯作者：
ROBERTS, GW
中科院分区：
文献类型：
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作者：
GENTLEMAN, SM;NASH, MJ;ROBERTS, GW
最近的研究表明，通常与阿尔茨海默病斑块相关的β-淀粉样蛋白（βAP）也可以在头部受伤幸存者的大脑中找到。在这项研究中，通过免疫组织化学检查了 betaAP 前体蛋白 (betaAPP) 的分布，以确定在这种情况下它是否与 betaAP 共定位。在新皮质的神经元核周和 betaAP 免疫反应斑块周围的营养不良神经突中观察到了 BetaAPP 免疫反应性，即分布与阿尔茨海默氏病中所见的分布相似。此外，在白质束内还发现了 betaAPP 免疫反应性，它标志着受损的轴突。然而，在任何白质区域均未观察到 betaAPP 与 betaAP 的共定位。这些结果表明，βAPP 加工产生 betaAP 发生在轴突的突触末端区域，并说明了 betaAPP 免疫反应性作为轴突损伤的通用标记物的效用。
It has been demonstrated recently that beta-amyloid protein (betaAP), generally associated with the plaques of Alzheimer's disease, can also be found in the brains of survivors of head injury. In this study the distribution of the betaAP precursor protein (betaAPP) was examined immunohistochemically to determine if it is colocalized with betaAP in such cases. BetaAPP immunoreactivity was observed in neuronal perikarya in the neocortex and in dystrophic neurites surrounding betaAP immunoreactive plaques i.e. in a distribution similar to that seen in Alzheimer's disease. In addition, betaAPP immunoreactivity was noted within white matter tracts where it marked damaged axons. However, no colocalisation of betaAPP with betaAP was observed in any white matter region. These results indicate that processing of betaAPP to produce betaAP occurs in the synaptic terminal field of axons and illustrate the utility of betaAPP immunoreactivity as a general marker for axonal injury.