THE HUMAN HEMATOPOIETIC COLONY-STIMULATING FACTORS
THE HUMAN HEMATOPOIETIC COLONY-STIMULATING FACTORS
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DOI：
10.1126/science.3296190
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发表时间：
1987-06-05
期刊：
影响因子：
56.9
通讯作者：
KAMEN, R
中科院分区：
文献类型：
--
作者：
CLARK, SC;KAMEN, R
互补DNA和编码四种主要的人类骨髓生长因子-粒细胞集落刺激因子、巨噬细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子和白细胞介素-3-的基因都已被分子克隆。这些DNA克隆已被证明对于研究这些重要调控分子的分子生物学以及大规模生产重组生长因子蛋白是有价值的。这些进展使我们对骨髓生长因子在体内调节造血中的作用有了更好的理解，这将很快在临床医学中得到实际应用。
The complementary DNAs and genes encoding the four major human myeloid growth factors—granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3—have all been molecularly cloned. These DNA clones have proved valuable for studying the molecular biology of these important regulatory molecules as well as for the large-scale production of the recombinant growth factor proteins. These advances have led to a much better understanding of the role of the myeloid growth factors in regulating hematopoiesis in vivo that should soon find practical application in clinical medicine.