Effects and mechanisms of natural products on Alzheimer’s disease
Effects and mechanisms of natural products on Alzheimer’s disease
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DOI：
10.1080/10408398.2021.1985428
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发表时间：
2021-10
影响因子：
10.2
通讯作者：
Zhijun Yang;Dan-Dan Zhou-Dan;Si-Yu Huang;Ai-Ping Fang;Huabin Li;Hui-lian Zhu
中科院分区：
文献类型：
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作者：
Zhijun Yang;Dan-Dan Zhou-Dan;Si-Yu Huang;Ai-Ping Fang;Huabin Li;Hui-lian Zhu
阿尔茨海默病（Alzheimer 's disease， AD）是老年人最常见的痴呆形式，发病率高，发病机制复杂，可导致进行性认知缺陷和记忆障碍。一些天然来源的天然产物和生物活性化合物，如苹果、蓝莓、葡萄、辣椒、山茱萸、十字花科蔬菜、羊尾草、当归、海参、灰树瓜、绿茶、普洱茶、金银花和斜凤梨等，通过减少β淀粉样蛋白（Aβ）沉积、降低Tau蛋白过度磷酸化、调节胆碱能系统，在预防和治疗AD方面显示出很大的潜力。减少氧化应激，抑制细胞凋亡，改善炎症。本文主要综述了一些天然产物及其生物活性化合物对AD的作用及其可能的分子机制。
Abstract Alzheimer’s disease (AD) is the most common form of dementia in elderly people with a high incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and memory impairment. Some natural products and bioactive compounds from natural sources show great potential in the prevention and treatment of AD, such as apple, blueberries, grapes, chili pepper, Monsonia angustifolia, cruciferous vegetables, Herba epimedii, Angelica tenuissima, Embelia ribes, sea cucumber, Cucumaria frondosa, green tea, Puer tea, Amanita caesarea and Inonotus obliquus, via reducing amyloid beta (Aβ) deposition, decreasing Tau hyperphosphorylation, regulating cholinergic system, reducing oxidative stress, inhibiting apoptosis and ameliorating inflammation. This review mainly summarizes the effects of some natural products and their bioactive compounds on AD with the potential molecular mechanisms.