Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study.
Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study.
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DOI：
10.1038/s41598-017-00941-y
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发表时间：
2017-04-11
影响因子：
4.6
通讯作者：
Kac G
中科院分区：
文献类型：
--
作者：
Farias DR;Poston L;Franco-Sena AB;Moura da Silva AA;Pinto T;de Oliveira LC;Kac G
妊娠期间母亲脂质、瘦素和脂联素浓度的变化和婴儿出生体重（BW）的特征仍然很差。因此，本研究的目的是评估妊娠期间母体脂质、瘦素和脂联素与大胎龄（LGA）出生和体重z-评分的关系。在巴西里约热内卢，对199名怀孕期间的母亲进行了前瞻性队列研究。统计分析包括多元逻辑回归和线性回归。女性分娩36例LGA新生儿和11例小于胎龄新生儿。整个妊娠期间HDL-c变化率与BW z-score （β = - 1.99; p = 0.003）和LGA新生儿的分娩（OR = 0.02; p = 0.043）呈负相关。妊娠基线对数瘦素浓度与低出生率呈正相关（OR = 3.92; p = 0.025）。妊娠期间LDL-c变化率与BW z-score呈正相关（β = 0.31; p = 0.004）。Log甘油三酯和Log脂联素与BW z-score或LGA出生无显著相关性。总之，较高的瘦素妊娠基线浓度和较低的妊娠期间HDL-c变化率与LGA新生儿的高几率相关。这些母体生物标志物对胎儿生长很重要，可用于产前护理，作为筛查有体重不足风险的妇女的额外策略。
The change in maternal lipid, leptin and adiponectin concentrations during pregnancy and infant birth weight (BW) is still poorly characterized. Thus, the aim of the study was to evaluate the association of maternal lipids, leptin and adiponectin throughout pregnancy with large-for-gestational-age (LGA) births and BW z-score. A prospective cohort of 199 mothers was followed during pregnancy in Rio de Janeiro, Brazil. The statistical analyses comprised multiple logistic and linear regression. Women delivered 36 LGA and 11 small-for-gestational-age newborns. HDL-c rate of change throughout pregnancy was negatively associated with BW z-score (β = −1.99; p = 0.003) and the delivery of a LGA newborn (OR = 0.02; p = 0.043). Pregnancy baseline concentration of log leptin was positively associated (OR = 3.92; p = 0.025) with LGA births. LDL-c rate of change throughout pregnancy was positively associated with BW z-score (β = 0.31; p = 0.004). Log triglycerides and log adiponectin were not significantly associated with BW z-score or LGA birth. In conclusion, a higher log leptin pregnancy baseline concentration and a lower HDL-c rate of change during pregnancy were associated with higher odds of having a LGA newborn. These maternal biomarkers are important to foetal growth and could be used in prenatal care as an additional strategy to screen women at risk of inadequate BW.