Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect
Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect
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具有增强光热效应的聚多巴胺包覆磁性复合粒子
DOI：
10.1021/acsami.5b03201
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发表时间：
2015-07-29
影响因子：
9.5
通讯作者：
Yang, Wuli
中科院分区：
文献类型：
--
作者：
Zheng, Rui;Wang, Sheng;Yang, Wuli
近年来，利用光热转换（PTC）药物在近红外（NIR）照射下消融肿瘤的光热疗法（PTT）因其优异的治疗效果和提高的靶点选择性而受到越来越多的关注。因此，开发具有优异光热效应的新型PTC药剂是当前的研究热点。本文报道了一种增强PTC效应的聚多巴胺包覆磁性复合粒子，该粒子通过在磁性Fe3O4粒子表面包覆聚多巴胺（PDA）而合成。与磁性Fe3O4粒子和PDA纳米球相比，核壳纳米材料的近红外吸收增强，从而获得了增强的光热效应。我们使用我们的复合颗粒证明了光热疗法的体外和体内效果，以及它们在t -2加权磁共振成像中作为造影剂的能力。这些结果表明，光热效应增强的多功能复合粒子优于磁性Fe3O4粒子和单独的PDA纳米球。
Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe3O4 particles. Compared with magnetic Fe3O4 particles and PDA nanospheres, the core-shell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T-2-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe3O4 particles and PDA nanospheres alone.