Increased error-related brain activity in pediatric obsessive-compulsive disorder before and after treatment
Increased error-related brain activity in pediatric obsessive-compulsive disorder before and after treatment
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DOI：
10.1176/appi.ajp.2007.07010143
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发表时间：
2008-01-01
影响因子：
17.7
通讯作者：
Simons, Robert F.
中科院分区：
文献类型：
--
作者：
Hajcak, Greg;Franklin, Martin E.;Simons, Robert F.
目的-错误相关负性是在错误发生后约50毫秒事件相关电位的最大负向偏转。错误相关的负性产生于前扣带皮层，并且在患有强迫症（OCD）的成年人中已经报道了前扣带皮层过度活跃和错误相关的大脑活动增加。然而，没有研究到目前为止，据作者所知，已经检查了错误相关的脑活动在儿童患者与强迫症，没有研究已经检查了错误相关的脑活动在强迫症之前和之后treatment.Method：错误相关的负性进行了测量，在18个寻求治疗的儿童患者与强迫症和18个年龄匹配的比较科目。在这些患者中，10个返回认知行为治疗后的第二次测试会议; 13个比较儿童参加了第二次后，可比intervation.Results：在预处理组，错误相关的负可靠较大的儿童强迫症患者在比较科目。这种差异在治疗后也很明显。错误相关的负性和症状的严重程度或症状severity.Conclusions的变化之间没有关系：与成人患者的研究一致，增加错误相关的大脑活动是明显的，在儿童强迫症患者。此外，错误相关的大脑活动增加似乎不会改变治疗后症状减轻的功能。这些结果表明，错误相关的负性增加可能是精神病理学的一个特征样标记，可能是一个有用的内在表型。
Objective- The error-related negativity is a negative deflection in the event-related potential maximal approximately 50 msec after the commission of errors. The error-related negativity is generated in the anterior cingulate cortex, and both anterior cingulate cortex hyperactivity and increased error-related brain activity have been reported in adults with obsessive-compulsive disorder (OCD). However, no study to date, to the authors' knowledge, has examined error-related brain activity in pediatric patients with OCD, and no study has examined error-related brain activity in OCD both before and after treatment.Method: The error-related negativity was measured in 18 treatment-seeking pediatric patients with OCD and 18 age-matched comparison subjects. Of these patients, 10 returned for a second testing session after cognitive behavior therapy; 13 comparison children participated a second time after a comparable interval.Results: In the pretreatment group, the error-related negativity was reliably larger in pediatric patients with OCD in relation to comparison subjects. This difference was also evident after treatment. There was no relationship between error-related negativity and symptom severity or changes in symptom severity.Conclusions: Consistent with studies in adult patients, increased error-related brain activity is evident in pediatric patients with OCD. Furthermore, increased error-related brain activity does not appear to change as a function of symptom reduction after therapy. These results suggest that an increased error-related negativity may be a trait-like marker for psychopathology and might be a useful endophenotype.