Integration of event experiences to build relational knowledge in the human brain
Integration of event experiences to build relational knowledge in the human brain
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DOI：
10.1093/cercor/bhad260
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发表时间：
2023-07-25
期刊：
影响因子：
3.7
通讯作者：
Ranganath，Charan
中科院分区：
文献类型：
--
作者：
Leshinskaya，Anna;Nguyen，Mitchell A.;Ranganath，Charan
我们研究了人类大脑如何整合特定事件的经验，以建立关于典型事件结构的一般知识。我们研究了一个重要的情景记忆区的时间关系，前外侧内嗅皮层，和一个重要的语义记忆区的行动概念，颞中回，了解如何以及何时这些领域有助于这些过程。参与者接受功能性磁共振成像，同时学习和回忆两个会议之间的时间关系的新事件间隔1周。在不同的上下文中，事件之间的个体时间关系可以是一致的，也可以是不一致的。在每一个背景下，在回忆阶段，我们测量了相关与不相关的事件对之间的多体素相关性的差异的关联编码。形成整合表征的神经区域在一致的情境中应该比在不一致的情境中表现出更强的联想编码。我们发现证据的综合性陈述，迅速出现在前外侧内嗅皮层（在会话1），只有随后在颞中回，这表明一个显着的变化跨会话。在学习过程中，发现了一种互补的模式与签名。这表明，整合表征建立在前外侧内嗅皮层的早期，可能是一个途径，后来出现的语义知识在颞中回。
We investigated how the human brain integrates experiences of specific events to build general knowledge about typical event structure. We examined an episodic memory area important for temporal relations, anterior-lateral entorhinal cortex, and a semantic memory area important for action concepts, middle temporal gyrus, to understand how and when these areas contribute to these processes. Participants underwent functional magnetic resonance imaging while learning and recalling temporal relations among novel events over two sessions 1 week apart. Across distinct contexts, individual temporal relations among events could either be consistent or inconsistent with each other. Within each context, during the recall phase, we measured associative coding as the difference of multivoxel correlations among related vs unrelated pairs of events. Neural regions that form integrative representations should exhibit stronger associative coding in the consistent than the inconsistent contexts. We found evidence of integrative representations that emerged quickly in anterior-lateral entorhinal cortex (at session 1), and only subsequently in middle temporal gyrus, which showed a significant change across sessions. A complementary pattern of findings was seen with signatures during learning. This suggests that integrative representations are established early in anterior-lateral entorhinal cortex and may be a pathway to the later emergence of semantic knowledge in middle temporal gyrus.