Influence of dietary calcium on sodium and calcium intake of spontaneously hypertensive rats.
Influence of dietary calcium on sodium and calcium intake of spontaneously hypertensive rats.
复制标题
膳食钙对自发性高血压大鼠钠和钙摄入量的影响。
DOI：
10.1152/ajpregu.1992.262.3.r370
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Tordoff,MG
中科院分区：
文献类型：
--
作者：
Tordoff,MG
与血压正常的 Wistar-Kyoto (WKY) 对照组相比，喂食完全营养饮食的自发性高血压大鼠 (SHR) 自愿摄入更多的钙和更多的氯化钠溶液。 SHR 的钙代谢也存在一些异常。鉴于钙的可用性调节其他大鼠品系的 NaCl 摄入量，我们检查了 SHR 的钠和钙摄入量是否对膳食钙的控制异常敏感。在三项实验中，SHR 和 WKY 组的饮食中钙含量不同（0-1,000 mmol/kg），并饮用钠溶液（50 和 300 mM 氯化钠或 50 mM 乳酸钠）和/或钙溶液（50 和 110 mM 乳酸钙或 50 mM CaCl2）。相对于WKYs，饲喂缺钙饮食（0 mmol Ca2+/kg）的SHR在首次引入饮食时饮用相同量或更少的钙溶液，饮用更多的氯化钠，并且更快地增加氯化钠摄入量。饲喂足以正常生长的饮食（50-1,000 mmol Ca2+/kg）的 SHR 始终比 WKY 喝更多的钙和钠溶液。然而，高钙饮食会降低 SHR 的 NaCl 摄入量，而 WKY 的 NaCl 摄入量则不会。总而言之，这些结果表明，依赖于钙的可用性的机制至少部分地导致了 SHR 的高盐摄入。
Spontaneously hypertensive rats (SHRs) fed nutritionally complete diets voluntarily ingest more calcium and more NaCl solution than do their normotensive Wistar-Kyoto (WKY) controls. SHRs also have several anomalies in calcium metabolism. Given that calcium availability modulates NaCl intake of other rat strains, we examined whether sodium and calcium intake of the SHR was unusually responsive to manipulations of dietary calcium. In three experiments, groups of SHRs and WKYs ate diets differing in calcium content (0-1,000 mmol/kg) and drank solutions of sodium (50 and 300 mM NaCl or 50 mM sodium lactate) and/or calcium (50 and 110 mM calcium lactate or 50 mM CaCl2). Relative to WKYs, SHRs fed calcium-deficient diet (0 mmol Ca2+/kg) drank the same amount or less calcium solution, drank more NaCl, and increased NaCl intake more rapidly when the diet was first introduced. SHRs fed diets sufficient for normal growth (50-1,000 mmol Ca2+/kg) drank consistently more calcium and sodium solution than did WKYs. However, NaCl intake of SHRs was decreased by high-calcium diets, whereas NaCl intake of WKYs was not. Taken together, these results suggest that a mechanism dependent on the availability of calcium is at least partially responsible for the high salt intake of the SHR.