Cancer nanotechnology: current status and perspectives.
Cancer nanotechnology: current status and perspectives.
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DOI：
10.1186/s40580-021-00282-7
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发表时间：
2021-11-02
期刊：
影响因子：
11.7
通讯作者：
Kwon YJ
中科院分区：
文献类型：
--
作者：
Kemp JA;Kwon YJ
现代医学对癌症的战争已经进行了将近世纪，但还没有明显的结束迹象。癌症治疗已经取得了显著进展，但仍然需要提高特异性和降低全身毒性。早期诊断是改善预后前景和患者生活质量的关键，诊断工具正处于技术革命的尖端。纳米技术已经稳步扩展到癌症化疗，放疗，诊断和成像的范围，证明了增强每一个和推进患者护理的能力。纳米材料提供了丰富的多功能性，功能性和应用程序，以设计专门针对癌症的药物，准确的早期检测设备，强大的成像模式和增强的放射治疗佐剂。本文综述了纳米技术在癌症药物治疗、诊断、成像和放射治疗中的临床和临床前应用。
Modern medicine has been waging a war on cancer for nearly a century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds a key to improving prognostic outlook and patient quality of life, and diagnostic tools are on the cusp of a technological revolution. Nanotechnology has steadily expanded into the reaches of cancer chemotherapy, radiotherapy, diagnostics, and imaging, demonstrating the capacity to augment each and advance patient care. Nanomaterials provide an abundance of versatility, functionality, and applications to engineer specifically targeted cancer medicine, accurate early-detection devices, robust imaging modalities, and enhanced radiotherapy adjuvants. This review provides insights into the current clinical and pre-clinical nanotechnological applications for cancer drug therapy, diagnostics, imaging, and radiation therapy.