Effects of supraphysiologic doses of testosterone on mood and aggression in normal men -: A randomized controlled trial
Effects of supraphysiologic doses of testosterone on mood and aggression in normal men -: A randomized controlled trial
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DOI：
10.1001/archpsyc.57.2.133
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发表时间：
2000-02-01
影响因子：
--
通讯作者：
Hudson, JI
中科院分区：
文献类型：
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作者：
Pope, HG;Kouri, EM;Hudson, JI
背景资料：对非法合成代谢雄激素类固醇使用者的实地研究表明，一些人对这些药物产生狂躁或攻击性反应，这是一个潜在的公共卫生问题。然而，控制实验室评价这些影响仍然limited.Methods：在一个随机，安慰剂对照，交叉试验，我们给予环戊丙酸睾酮6周的剂量上升到600毫克/周和安慰剂6周，分开6周的无治疗，56名男性年龄在20至50岁。精神病学结果测量包括杨氏躁狂评定量表（YMRS）、点减攻击范式、（一种计算机化的攻击性激发测试）、Buss和佩里的攻击性问卷、症状自评量表-90-R、躁狂和抑郁症状的每日日记，以及由一位非常了解参与者的“重要他人”完成的类似的每周日记。替吉奥治疗显著增加了YMRS的躁狂评分（P = 0.002），每日日记的躁狂评分（P= 0.003），喜欢药物效果的视觉模拟评级（P = 0.008），以及点减法攻击范式的攻击性反应（P = 0.03）。药物反应是高度可变的：在接受600 mg/wk环戊丙酸睾酮的50名参与者中，42名（84%）表现出最小的精神影响（最大YMRS评分，
Background: Field studies of illicit anabolic-androgenic steroid users suggest that some develop manic or aggressive reactions to these drugs-a potential public health problem. However, controlled laboratory evaluations of these effects remain limited.Methods: In a randomized, placebo-controlled, crossover trial, we administered testosterone cypionate for 6 weeks in doses rising to 600 mg/wk and placebo for 6 weeks, separated by 6 weeks of no treatment, to 56 men aged 20 to 50 years. Psychiatric outcome measures included the Young Mania Rating Scale (YMRS), the Point Subtraction Aggression Paradigm (a computerized provocation test of aggression), the Aggression Questionnaire of Buss and Perry, the Symptom Checklist-90-R, daily diaries of manic and depressive symptoms, and similar weekly diaries completed by a "significant other" who knew the participant well.Results: Testosterone treatment significantly increased manic scores on the YMRS (P =.002), manic scores on daily diaries (P=.003), visual analog ratings of liking the drug effect (P =.008), and aggressive responses on the Point Subtraction Aggression Paradigm (P =.03). Drug response was highly variable: of 50 participants who received 600 mg/wk of testosterone cypionate, 42 (84%) exhibited minimal psychiatric effects (maximum YMRS score,