ABNORMAL VISUAL PATHWAYS IN NORMALLY PIGMENTED CATS THAT ARE HETEROZYGOUS FOR ALBINISM
ABNORMAL VISUAL PATHWAYS IN NORMALLY PIGMENTED CATS THAT ARE HETEROZYGOUS FOR ALBINISM
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DOI：
10.1126/science.3929383
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
CREEL, DJ
中科院分区：
文献类型：
--
作者：
LEVENTHAL, AG;VITEK, DJ;CREEL, DJ
在美国，各种形式的白化病影响着大约10000名新生儿中的一名。另有1%到2%的人有正常的色素沉着，但是杂合子，并携带白化病的隐性等位基因。研究了携带白化病隐性等位基因的正常色素猫的视网膜生发皮质通路。这些猫在视觉路径上表现出异常，类似于纯合子白化病患者的情况。这些结果表明，1%到2%的人可能会出现像白化病患者那样的视觉异常。
The various forms of albinism effect about one in 10,000 births in the United States. An additional 1 to 2 percent of the population has normal pigmentation but is heterozygous and carries a recessive allele for albinism. The retinogeniculocortical pathways were studied in normally pigmented cats that carry a recessive allele for albinism. The cats exhibited abnormalities in their visual pathways similar to those present in homozygous albinos. These results imply that visual anomalies like those found in albinos may be present in 1 to 2 percent of the human population.