REGIONAL DISTRIBUTION OF ASCORBATE AND 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) IN RAT STRIATUM
REGIONAL DISTRIBUTION OF ASCORBATE AND 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) IN RAT STRIATUM
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DOI：
10.1016/0006-8993(91)90372-3
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发表时间：
1991-01-04
期刊：
影响因子：
2.9
通讯作者：
REBEC, GV
中科院分区：
文献类型：
--
作者：
BASSETOMUSK, A;REBEC, GV
用在体伏安法研究了多巴胺主要代谢产物3，4-二羟基苯乙酸（DOPAC）和细胞外抗坏血酸（AA）在大鼠纹状体的区域分布。 电化学修饰的碳纤维电极，它提供了不同的氧化曲线，这些物质中的每一个，降低了1毫米的增量通过四个纹状体区域选择的采样整个范围内的这种结构，包括髓核。在前内侧纹状体中，AA水平在最背侧和腹侧最高，在中间最低，而DOPAC水平一般表现出相反的模式。 AA和DOPAC之间的这种反向关系在外侧或后部区域都不明显。 在一定程度上，AA和DOPAC从不同的轴突末梢释放，越来越多的证据表明，这些化合物的细胞外浓度的区域差异可能反映了不同的，在某些情况下，两个神经元群体的相互分布。
In vivo voltammetry was used to study the regional distribution of extracellular ascorbate (AA) and 3,4-dihydroxyphenylacetic acid (DOPAC), a major dopamine metabolite, in the striatum of the rat. An electrochemically-modified carbon-fiber electrode, which provides distinct oxidation curves for each of these substances, was lowered in 1-mm increments through one of four striatal regions selected to sample the entire extent of this structure, including the nucleus accumbens. In anteromedial striatum, the level of AA was highest in the most dorsal and ventral aspects and lowest in the middle, whereas DOPAC levels generally showed the opposite pattern. This inverse relationship between AA and DOPAC was not evident in either lateral or posterior areas. To the extent that AA and DOPAC are released from different axon terminals, as mounting evidence suggests, regional differences in the extracellular concentration of these compounds may reflect the different and in some cases, reciprocal distributions of two neuronal populations.