Vitamin D, homocysteine and n-3PUFA status according to physical and cognitive functions in older adults with subjective memory complaint: Results from cross-sectional study of the MAPT trial
Vitamin D, homocysteine and n-3PUFA status according to physical and cognitive functions in older adults with subjective memory complaint: Results from cross-sectional study of the MAPT trial
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DOI：
10.1016/j.exger.2018.07.006
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发表时间：
2018-10-01
影响因子：
3.9
通讯作者：
Vellas, B.
中科院分区：
文献类型：
--
作者：
Chhetri, J. K.;Barreto, P. de Souto;Vellas, B.
目的：本研究的目的是调查的营养标志物（维生素D，同型半胱氨酸，n -3多不饱和脂肪酸）状态的老年人年龄在70岁及以上的主观记忆投诉，根据他们的身体和认知function.Main结果的措施：这项研究是一个次要的分析MAPT研究。受试者分为四组：1）身体限制伴认知障碍（PLCI），2）认知障碍（CI），3）身体限制（PL）和4）无身体或认知缺陷（NPCD）。根据维生素D（n = 732）、Omega-3多不饱和脂肪酸（n -3 PUFA）（n = 1537）和血浆总同型半胱氨酸（tHcy）（n = 729）状况调查四组的基线营养特征。采用维生素D不足（[25（OH）D] < 30 ng/ml，高同型半胱氨酸水平（tHcy >= 15 μ mol/L）和低n -3 PUFA（DHA + EPA））的连续和二分值进行分析
Objective: The aim of this study was to investigate the nutritional markers (Vitamin D, homocysteine, n - 3PUFA) status of older subjects aged 70 years and older with subjective memory complaint, according to their physical and cognitive function.Main outcome measures: This study is a secondary analysis of the MAPT study. Subjects were classified into four groups: 1) Physical limitation with cognitive impairment (PLCI), 2) cognitive impairment (CI), 3) physical limitation (PL) and 4) no physical or cognitive deficits (NPCD). Baseline nutritional characteristics of the four groups according to Vitamin D (n = 732), Omega-3 polyunsaturated fatty acid (n - 3PUFA) (n = 1537) and plasma total homocysteine (tHcy) (n = 729) status were investigated. Analysis was performed taking continuous and dichotomized value for Vitamin D insufficiency ([25(OH)D] < 30 ng/ml, high homocysteine level (tHcy >= 15 mu mol/L) and low n - 3PUFA (DHA + EPA