The metabolic syndrome: Linking oxidative stress and inflammation to obesity, type 2 diabetes, and the syndrome
The metabolic syndrome: Linking oxidative stress and inflammation to obesity, type 2 diabetes, and the syndrome
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DOI：
10.1002/ddr.20137
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发表时间：
2006-07-01
影响因子：
3.8
通讯作者：
Chaudhuri, Ajay
中科院分区：
文献类型：
--
作者：
Dandona, Paresh;Ghanim, Husam;Chaudhuri, Ajay
代谢综合征由一组临床特征定义，可增加心血管疾病和2型糖尿病的风险。最初的假说将这种综合征与这些疾病联系起来，是基于胰岛素抵抗和高胰岛素血症对动脉粥样硬化的影响。然而，炎症过程现在已经与动脉粥样硬化和胰岛素抵抗的发病机制相关联。新的数据已经显示了大量营养素对炎症介质的影响以及响应于食物摄入而分泌的胰岛素的抗炎作用。本文试图在此基础上对代谢综合征的发病机制以及心血管疾病和糖尿病风险的增加提供一种新的解释。
Metabolic syndrome defined by a cluster of clinical features increases the risk of cardiovascular disease and type 2 diabetes mellitus. The original hypothesis linking this syndrome to these diseases was based on insulin resistance and the effect of hyperinsulinemia on atherogenesis. However, inflammatory processes have now been linked to the pathogenesis of atherosclerosis and insulin resistance. Novel data have shown the effect of macronutrients on inflammatory mediators and the anti-inflammatory effects of insulin that is secreted in response to food intake. This review attempts to provide an alternative explanation for the pathogenesis of the metabolic syndrome and the increase in risk of cardiovascular disease and diabetes on the basis of these findings.