Hyaluronan enters keratinocytes by a novel endocytic route catabolism
Hyaluronan enters keratinocytes by a novel endocytic route catabolism
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DOI：
10.1074/jbc.m103481200
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发表时间：
2001-09-14
影响因子：
4.8
通讯作者：
Tammi, M
中科院分区：
文献类型：
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作者：
Tammi, R;Rilla, K;Tammi, M
在表皮中合成的透明质酸具有非常短的半衰期，这表明它是由表皮角质形成细胞分解代谢的。在培养的大鼠表皮角质形成细胞中，观察到细胞内内源性合成的透明质酸池，从1到20 fg/细胞，与细胞密度成反比。超过80%的细胞内透明质酸是小的(
Hyaluronan synthesized in the epidermis has an exceptionally short half-life, indicative of its catabolism by epidermal keratinocytes. An intracellular pool of endogenously synthesized hyaluronan, from 1 to 20 fg/cell, inversely related to cell density, was observed in cultured rat epidermal keratinocytes. More than 80% of the intracellular hyaluronan was small (