Intracortical inhibition and facilitation are impaired in patients with early Parkinson's disease:: a paired TMS study
Intracortical inhibition and facilitation are impaired in patients with early Parkinson's disease:: a paired TMS study
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DOI：
10.1046/j.1468-1331.2003.00610.x
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发表时间：
2003-07-01
影响因子：
5.1
通讯作者：
Rektor, I
中科院分区：
文献类型：
--
作者：
Bares, M;Kanovsky, P;Rektor, I
使用经颅磁刺激 (TMS) 对 12 名早期帕金森病 (PD) 患者进行了研究，他们之前均未接受过任何左旋多巴治疗，但使用过其他抗帕金森病药物。检查对侧和同侧半球，重点关注更明显的帕金森症状。通过刺激圆形线圈使用条件测试 TMS 范例（具有阈下条件刺激和阈上测试刺激）。短（3、5 和 7 毫秒）、中（10、15 和 20 毫秒）和长（100、150、200 和 250 毫秒）刺激间隔 (ISI) 的配对刺激与单个刺激伪随机混合。第一骨间肌用于运动诱发电位记录。以相同的方式研究十名健康受试者（年龄和性别匹配）以获得规范数据。两组比较时，PD患者与对照组在两个半球的短和中ISI（3、5、7、10、15和20 ms）时发现显着差异（P < 0.05）。较长的 ISI 使两组之间的皮质内兴奋性没有显着差异。运动阈值没有显着差异。总之，可以推测，对于使用左旋多巴或多巴胺激动剂以外的其他抗帕金森病治疗的早期帕金森病患者，皮质内抑制和促进都会受到损害。
Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian symptoms. The conditioning-test TMS paradigm (with a subthreshold conditioning stimulus and a suprathreshold test stimulus) was used through a stimulating round coil. Paired stimuli of short (3, 5 and 7 ms), medium (10, 15 and 20 ms), and long (100, 150, 200 and 250 ms) interstimulus intervals (ISI) were pseudo-randomly mixed with a single stimulus. The first interosseus muscle was used for the motor-evoked potential recordings. Ten healthy subjects (age and sex matched) were studied in the same manner to obtain normative data. When both groups were compared, the significant difference (reduction of the intracortical inhibition and facilitation) between the PD patients and the control group was found at the short and the medium ISI (3, 5, 7, 10, 15 and 20 ms) in both hemispheres (P < 0.05). The longer ISI produced non-significant differences between the two groups in intracortical excitability. There was a non-significant difference in the motor threshold. In conclusion, it can be supposed that both intracortical inhibition and facilitation are impaired in patients with early PD using other antiparkinsonian treatments than L-DOPA or dopamine agonists.