Three-dimensional whole-liver perfusion magnetic resonance imaging in patients with hepatocellular carcinomas and colorectal hepatic metastases.
Three-dimensional whole-liver perfusion magnetic resonance imaging in patients with hepatocellular carcinomas and colorectal hepatic metastases.
复制标题
肝细胞癌及结直肠肝转移患者的三维全肝灌注磁共振成像
DOI：
10.1186/1471-230x-13-53
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发表时间：
2013-03-25
影响因子：
2.4
通讯作者：
Qu XD
中科院分区：
文献类型：
--
作者：
Rao SX;Chen CZ;Liu H;Zeng MS;Qu XD
三维（3D）全肝灌注磁共振（MR）成像并行成像是一种新的表征肿瘤体内血管化的成像方法，近年来已被应用于大肿瘤灌注变化的综合成像。结合新的灌注软件，该技术可以实现灌注MR参数的运动校正、配准和评估。本研究的目的是评估3D全肝灌注MR成像肝细胞癌（HCC）和结直肠癌肝转移瘤（CRHM）的可行性。方法对26例肝脏肿瘤患者（HCC 10例，CRHM 16例）进行三维全肝灌注MR扫描，扫描时间分辨率为3.7 s。测量以下估计灌注参数：体积传递常数Ktrans(min-1)；单位体积组织的血管外细胞外间隙（EES）体积（Ve）；EES与等离子体之间的通量常数为p（min-1）。进行统计分析，以调查观察者间的特征和测量参数的显著性。结果经观察者间一致性分析（95%一致性限），Ktrans的平均差异为- 0.0048 min-1(- 0.0598 ~ 0.0502)， Ve的平均差异为-0.0630 ml (- 0.5405 ~ 0.4145)， kek的平均差异为- 0.0031 min-1（- 0.0771 ~ 0.0709）。当比较HCC患者与CRHM患者的图像时，平均Ktrans有显著差异（p = 0.017），但Ve（p = 0.117）或Kep（p = 0.595）没有显著差异。结论采用半自动化数据分析的三维全肝MR灌注成像技术是可行的，可以可靠地定量评估hcc和crhm的灌注参数。
BackgroundThree-dimensional (3D) whole-liver perfusion magnetic resonance(MR) imaging with parallel imaging, a novel imaging method to characterize tumor vascularizationin vivo,has recently been applied to comprehensively image perfusion changes in large tumors. Coupled with new perfusion software, this technique enables motion correction, registration, and evaluation of perfusion MR parameters. The purpose of this study was to assess the feasibility of 3D whole-liver perfusion MR, for imaging hepatocellular carcinoma (HCC) and colorectal hepatic metastases (CRHM).Methods26 patients with hepatic tumors (10 HCC; 16 CRHM) were subjected to 3D whole-liver perfusion MR with a temporal resolution of 3.7 seconds. The following estimated perfusion parameters were measured: the volume transfer constant Ktrans(min-1); the volume (Ve) of extravascular extracellular space (EES) per volume unit of tissue; and the flux rate constant between EES and plasma Kep(min-1). Statistical analysis was conducted to investigate inter-observer characteristics and significance of the measured parameters.ResultsInter-observer agreement analysis (95% limits of agreement) yielded a mean difference of −0.0048 min-1(−0.0598 ~ 0.0502) for Ktrans, -0.0630 ml (−0.5405 ~ 0.4145) for Ve, and −0.0031 min-1(−0.0771 ~ 0.0709) for Keprespectively. When comparing images from patients with HCC vs. CRHM, significant differences were seen for the mean Ktrans(p = 0.017), but not for Ve(p = 0.117) or Kep(p = 0.595).ConclusionHerein we show that 3D whole-liver MR perfusion imaging with semi-automatic data analysis is feasible and enables the reliable quantitative evaluation of the perfusion parameters for HCCs and CRHMs.