In utero DNA immunisation. Immunity over tolerance in fetal life.
In utero DNA immunisation. Immunity over tolerance in fetal life.
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子宫内 DNA 免疫。
DOI：
10.1016/j.vaccine.2004.11.046
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发表时间：
2005
期刊：
影响因子：
5.5
通讯作者：
Zanetti,Maurizio
中科院分区：
文献类型：
--
作者：
Rizzi,Marta;Gerloni,Mara;Srivastava,AnandS;Wheeler,MatthewC;Schuler,Kilian;Carrier,Ewa;Zanetti,Maurizio
半个世纪以来，发育中的免疫系统在胚胎生命中的功能和可塑性一直是免疫学思想的中心。一个经典的观点是，胎儿生命中遇到的抗原会导致获得性免疫耐受状态。然而，在围产期发展T细胞免疫反应的能力对于对抗细胞内病原体将是非常重要的。最近的实验挑战了这一概念，并表明新生儿的耐受性可以通过外部免疫操作来规避。在这里，我们使用针对B淋巴细胞的DNA免疫来诱导可以在出生后2周测量的CD4T细胞反应。我们的结论是，T细胞免疫可以在子宫内通过控制胎儿环境中的免疫反应参数来编程。此外，我们的数据表明，在适当的条件下，胎儿免疫系统可以编程为免疫。
The function and plasticity of the developing immune system during embryonic life has been central to immunological thinking for half a century. A classical view is that antigen encountered during fetal life induces a state of acquired immunological tolerance. However, the ability to develop T cell immune responses during the perinatal period would be of great importance against intracellular pathogens. Recent experiments have challenged this notion and shown that neonatal tolerance can be circumvented by extrinsic immunological manipulations. Here, we used DNA immunization targeted at B lymphocytes to induce a CD4 T cell response that could be measured 2 weeks after birth. We conclude that T cell immunity can be programmed in utero by manipulating the parameters of the immune response in the fetal environment. Furthermore, our data suggest that under appropriate conditions the fetal immune system can be programmed to immunity.