Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings.
Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings.
复制标题
百日咳毒素可防止腺苷的抑制作用并揭示腺苷诱导的哺乳动物运动神经末梢的兴奋。
DOI：
10.1111/j.1476-5381.1989.tb11918.x
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发表时间：
1989
影响因子：
7.3
通讯作者：
Hirsh,JK
中科院分区：
文献类型：
--
作者：
Silinsky,EM;Solsona,C;Hirsh,JK
百日咳毒素（PTX）可阻断某些类型的鸟嘌呤核苷酸结合蛋白（G蛋白），持续阻断腺苷（100 μm ~ 250 μm）对大鼠膈神经半膈制剂中量子乙酰胆碱（ACh）分泌的抑制作用。PTX预处理还强调了腺苷引起的乙酰胆碱释放的持久增加。结果表明，特定的G蛋白参与了腺苷在运动神经末梢的抑制作用。
Pertussis toxin (PTX), which blocks certain classes of guanine nucleotide binding proteins (G proteins), consistently blocked the inhibitory effects of adenosine (100 μm‐250 μm) on quantal acetylcholine (ACh) secretion in rat phrenic nerve hemidiaphragm preparations. PTX pretreatment also highlighted long‐lasting increases in evoked ACh release elicited by adenosine. The results suggest that specific G proteins are involved in mediating the inhibitory effects of adenosine at motor nerve endings.