Fundamental aspects of reactive oxygen species, or what's the matter with oxygen?
Fundamental aspects of reactive oxygen species, or what's the matter with oxygen?
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DOI：
10.1111/j.1749-6632.1999.tb07814.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Fridovich, I
中科院分区：
文献类型：
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作者：
Fridovich, I
正常有氧代谢的副产品是产生O-2还原的危险活性中间体。其中包括O-2（-）、H2 O2和HO。并且由于O-2对单价还原的倾向性而产生。这些活性氧（ROS）和它们可能产生的其他物质会威胁所有细胞大分子，因此需要进行防御。迄今已知的有：将O-2（-）转化为O-2 + H2 O2的超氧化物歧化酶;将H2 O2转化为O-2 + H2O的过氧化氢酶;将H2 O2还原为2 H（2）O并将ROOH还原为ROH和H2O的过氧化物酶。这些防御由修复或回收氧化损伤的核酸和蛋白质的酶辅助。这种氧化损伤在衰老和神经退行性疾病中的作用得到了很好的支持。
A byproduct of normal aerobic metabolism is the generation of dangerously reactive intermediates of the reduction of O-2. These include O-2(-), H2O2, and HO . and arise because of the predisposition of O-2 for univalent reductions. These reactive oxygen species (ROS), and others that they can engender, threaten all cellular macromolecules, and defenses are needed. Among those known to date are: superoxide dismutases to convert O-2(-) into O-2 + H2O2; catalases to dismute H2O2 into O-2 + H2O; and peroxidases to reduce H2O2 into 2H(2)O) and to reduce ROOH into ROH and H2O, These defenses are aided by enzymes that repair or recycle oxidatively damaged nucleic acids and proteins. A role for such oxidative damage in aging and neurodegenerative diseases is well supported.