Modelling induced currents in biological cells exposed to low-frequency magnetic fields.
Modelling induced currents in biological cells exposed to low-frequency magnetic fields.
复制标题
对暴露于低频磁场的生物细胞中的感应电流进行建模。
DOI：
10.1088/0031-9155/39/9/001
复制
发表时间：
1994
影响因子：
3.5
通讯作者：
W. Xi
中科院分区：
文献类型：
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作者：
M. Stuchly;W. Xi
低频磁场与生物系统的相互作用一直是科学探究和公众关注的主题。大多数研究都是在50赫兹或60赫兹的电力线频率下进行的。低频磁场与生物系统相互作用的关键问题之一是暴露场的哪些参数对所观察到的效应负责。了解各种体外实验系统中的感应电场和电流对于这一目的是很重要的。本研究采用三维阻抗方法模拟了两种制备细胞中感应电场和电流的空间分布。考虑具有随机分布的细胞单层和具有间隙连接的细胞汇合单层；由于计算方法的局限性，生物细胞用立方体表示，而不是更现实的形状（例如球体）。随机模型表明，对于较高的电池密度，感应电流的模式对放置电池的容器的大小和形状有有限的依赖，它主要取决于实际的电池放置位置。不出所料，缝隙连接会增加电流密度，但前提是它们的电阻足够低。最大的电流密度出现在间隙中。
Interactions of low-frequency magnetic fields with biological systems have been a subject of intense scientific inquiry and public concern. Most research has been done at powerline frequencies of 50 Hz or 60 Hz. One of the key questions related to interactions of low-frequency magnetic fields with biological systems is which parameters of the exposure field are responsible for observed effects. Knowledge of the induced electric field and current in various experimental in vitro systems is important for this purpose. The 3D impedance method is used in this research to model spatial patterns of induced electric fields and current in two preparations of cells. A cell monolayer with a random distribution of cells and a confluent monolayer of cells with gap junctions are considered; because of the limitations of the computational method, biological cells are represented by cubes rather than more realistic shapes (e.g. spheres). The random model indicates that for higher cell densities the pattern of the induced current flow has a limited dependence on the size and shape of the container in which the cells are placed, it depends mostly on the actual cell placement. Gap junctions, not surprisingly, are shown to increase the current density, but only if their resistance is sufficiently low. The highest current density occurs in the gaps.
影响因子：
--
作者：
K. Foster;H. Schwan
通讯作者：
K. Foster;H. Schwan