Narrow band UVB (311 nm), psoralen UVB (311 nm) and PUVA therapy in the treatment of early-stage mycosis fungoides: a right-left comparative study
Narrow band UVB (311 nm), psoralen UVB (311 nm) and PUVA therapy in the treatment of early-stage mycosis fungoides: a right-left comparative study
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DOI：
10.1111/j.1600-0781.2005.00183.x
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发表时间：
2005-12-01
影响因子：
2.6
通讯作者：
El-Enany, G
中科院分区：
文献类型：
--
作者：
El-Mofty, M;El-Darouty, M;El-Enany, G
背景：长波紫外线（PUVA）是治疗早期皮肤T细胞淋巴瘤的一线药物。窄波段UVB（UVB-NB）（311 nm）最近被引入作为另一种有效的治疗线。目的：比较PUVA和UVB-NB治疗早期MF的临床和组织病理学疗效（IA、IB和IIA期），并评估是否peptide增加了UVB-NB的功效。将20名患者（IA、IB或IIA期）分为两个相等的组：I组在右半身体上接受UVB-NB，而在身体左侧接受PUVA，持续48个疗程; II组在身体右侧接受PUVB-NB，而在身体左侧接受PUVA，持续36个疗程。结果：在第一组中，几乎相同的结果，双方获得，即，UVB-NB和PUVA在治疗早期MF的临床和组织病理学方面同样有效。在第二组中，PUVB-NB被认为是有效的常规PUVA在治疗早期蕈样肉芽肿，也在临床和组织病理学grounds.Conclusion：UVB-NB光疗应包括在蕈样肉芽肿的初始治疗方案，鉴于其疗效，方便，和可能性少的长期不良反应。添加补骨脂素似乎并不能提高其疗效。
Background: Psoralen ultraviolet A (PUVA) is a widely used first-line therapy for treatment of early cutaneous T-cell lymphoma. Narrow band UVB (UVB-NB) (311 nm) has been recently introduced as another effective line of treatment. It is postulated that the efficacy of UVB-NB could be enhanced by addition of psoralen.Aim: The aim of the present work was to compare the clinical and histopathologic efficacy of PUVA and UVB-NB in the treatment of early-stage MF (stages IA, IB and IIA), and to evaluate whether psoralen adds to the efficacy of UVB-NB or not.Patients and Methods: Twenty patients (stage IA, IB or IIA) were divided into two equal groups: group I received UVB-NB on the right body half vs. PUVA on the left side of the body for 48 sessions, and group II received PUVB-NB on the right side of the body vs. PUVA on the left side for 36 sessions. The sessions were administered three times weekly.Results: In group I, almost equal results were obtained on both sides, i.e., UVB-NB and PUVA were equally effective in the treatment of early stages of MF, both clinically and histopathologically. In group II, PUVB-NB was found to be as effective as conventional PUVA in the treatment of early-stage mycosis fungoides, also on both clinical and histopathological grounds.Conclusion: UVB-NB phototherapy should be included among the initial therapeutic options of mycosis fungoides in view of its efficacy, convenience, and likelihood of fewer long-term adverse effects. Addition of psoralen does not seem to enhance its therapeutic efficacy.