AID is required for c-myc/IgH chromosome translocations in vivo
AID is required for c-myc/IgH chromosome translocations in vivo
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DOI：
10.1016/j.cell.2004.08.006
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发表时间：
2004-08-20
期刊：
影响因子：
64.5
通讯作者：
Nussenzweig, MC
中科院分区：
文献类型：
--
作者：
Ramiro, AR;Jankovic, M;Nussenzweig, MC
c-myc和免疫球蛋白（IG）之间的染色体易位与人类伯基特淋巴瘤和降植烷和IL 6诱导的小鼠浆细胞瘤相关。这些易位经常涉及IG开关区域，表明它们可能是异常的IG类开关重组（CSR）的结果。然而，CSR和染色体易位之间的直接联系尚未建立。我们已经研究了c-myc/IgH易位在IL 6转基因小鼠，是激活诱导的胞苷脱氨酶（AID），启动CSR的酶突变。我们报道AID在IL 6诱导的c-myc/IgH染色体易位中起重要作用。
Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Her a we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.