MOLECULAR-STRUCTURE OF LECITHIN DIHYDRATE
MOLECULAR-STRUCTURE OF LECITHIN DIHYDRATE
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DOI：
10.1038/281499a0
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发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
PASCHER, I
中科院分区：
文献类型：
--
作者：
PEARSON, RH;PASCHER, I
卵磷脂是生物膜的主要结构成分1,2。由于卵磷脂和相关磷脂的两亲性，它们倾向于聚集成双层结构，其中亲水性头基团朝向表面，疏水性烃链朝向内部。卵磷脂三维结构的详细知识将有助于理解它们在膜结构和功能中的作用，但仍然缺乏。为此，我们现在已经结晶并解决了1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱（DMPC）的分子结构，这是一种天然存在的卵磷脂。这种化合物在含水溶液中结晶，其中有两个水分子（5% w/w）的水合作用。
Lecithin is a major structural component of biological membranes1,2. Because of their amphipathic nature, lecithin and related phospholipids tend to aggregate as bilayer structures in which the hydrophilic head groups are orientated towards the surface and the hydrophobic hydrocarbon chains towards the interior. A detailed knowledge of the three-dimensional structure of lecithins will aid in the understanding of their role in membrane structure and function, but is still lacking. To this end we have now crystallised and solved the molecular structure of 1,2-dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC), a lecithin species in the naturally occurring configuration. This compound crystallises from a water-containing solution, with two water molecules (5% w/w) of hydration.