W(CO)5-amine catalyzed exo- and endo-selective cyclizations of omega-alkynyl silyl enol ethers: a highly useful method for the construction of polycyclic compounds.
W(CO)5-amine catalyzed exo- and endo-selective cyclizations of omega-alkynyl silyl enol ethers: a highly useful method for the construction of polycyclic compounds.
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DOI：
10.1021/ol026202c
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发表时间：
2002-06
期刊：
影响因子：
5.2
通讯作者：
H. Kusama;H. Yamabe;N. Iwasawa
中科院分区：
文献类型：
--
作者：
H. Kusama;H. Yamabe;N. Iwasawa
本文报道了一种以W(CO)5L催化ω -炔基硅烯醚的胺控外选择性和内选择性环化反应为基础构建多环化合物的有效方法。以W(CO)6、DABCO和水为催化量，在光照射下对双炔基硅烯醇醚进行处理，得到了合成有用的三环酮，收率较高。
[reaction: see text] A highly useful method for the construction of polycyclic compounds based on the amine-controlled exo- and endo-selective cyclizations of omega-alkynyl silyl enol ethers catalyzed by W(CO)5L is reported. When bis-alkynyl silyl enol ethers were treated with a catalytic amount of W(CO)6, DABCO, and water under photoirradiation, synthetically useful tricyclic ketones were obtained in good yield.