DISTRIBUTION OF BLOOD FLOW IN ISOLATED LUNG - RELATION TO VASCULAR + ALVEOLAR PRESSURES
DISTRIBUTION OF BLOOD FLOW IN ISOLATED LUNG - RELATION TO VASCULAR + ALVEOLAR PRESSURES
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DOI：
10.1152/jappl.1964.19.4.713
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发表时间：
1964-01-01
影响因子：
3.3
通讯作者：
NAIMARK, A
中科院分区：
文献类型：
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作者：
WEST, JB;DOLLERY, CT;NAIMARK, A
取犬左肺，负压通气，静脉血灌注。肺动脉、静脉和肺泡压力可以在很大范围内变化。用Xel33测定肺血流分布。在这些条件下，没有血流量高于肺泡等于动脉压的水平（在动脉插管处测量）。低于这个水平，当静脉压保持在较低水平时，血液流向肺部呈线性增加。在静脉压力与肺泡压力相等的区域内，升高静脉压力使血流分布更加均匀，但在此区域以下仍有血流增加。血流分布完全可以用血管内外压力的机械效应来解释，这两个压力都表现得像斯塔林阻力。模拟人体在各种生理和疾病状态下的血流分布是可能的。
The left lung from a dog was removed, ventilated with negative pressure, and perfused with venous blood. Pulmonary arterial, venous, and alveolar pressures could be varied over a large range. The distribution of blood flow in the lung was measured with Xel33. Under these conditions, there was no blood flow above the level at which alveolar equaled arterial pressure (measured at the arterial cannula). Below this level there was a linear increase in blood flow down the lung when the venous pressure was kept low. Raising the venous pressure made the distribution of flow more uniform below the level at which venous and alveolar pressures were equal although flow still increased down this zone. The flow distribution could be completely accounted for by the mechanical effects of the pressure inside and outside the blood vessels which each behaved like a Starling resistance. It was possible to simulate the flow distributions found in man in various physiological and diseased states.