Construction of a network describing asparagine metabolism in plants and its application to the identification of genes affecting asparagine metabolism in wheat under drought and nutritional stress.
Construction of a network describing asparagine metabolism in plants and its application to the identification of genes affecting asparagine metabolism in wheat under drought and nutritional stress.
复制标题
DOI：
10.1002/fes3.126
复制
发表时间：
2018-03
影响因子：
5
通讯作者：
Halford NG
中科院分区：
文献类型：
--
作者：
Curtis TY;Bo V;Tucker A;Halford NG
使用拟南芥 (Arabidopsis thaliana)、玉米 (Zea mays)、小麦 (Triticum aestivum)、豌豆 (Pisum sativum)、大豆 (Glycine max)、羽扇豆 (Lupus albus) 和其他物种（包括动物）的已发表数据构建了描述植物中天冬酰胺代谢的详细网络。天冬酰胺的合成和降解是植物氨基酸和氮代谢的主要部分。其代谢的复杂性（包括限制因素和调节因素）以使用 yED 图形编辑器软件构建的通路图中的逻辑顺序表示。该网络与独特的网络识别管道一起用于分析 18 项公开转录组数据研究的数据。这确定了干旱胁迫下的小麦根、干旱胁迫下的小麦叶以及硫和氮缺乏条件下的小麦叶中参与天冬酰胺代谢的基因之间的联系。该网络不仅可以帮助解释通路中基因之间的相互作用，还可以解释酶、代谢物和小分子之间的相互作用。它提供了对天冬酰胺代谢复杂性的简洁、清晰的理解，有助于解释与更广泛的氨基酸代谢和其他代谢过程相关的数据。
A detailed network describing asparagine metabolism in plants was constructed using published data from Arabidopsis (Arabidopsis thaliana) maize (Zea mays), wheat (Triticum aestivum), pea (Pisum sativum), soybean (Glycine max), lupin (Lupus albus), and other species, including animals. Asparagine synthesis and degradation is a major part of amino acid and nitrogen metabolism in plants. The complexity of its metabolism, including limiting and regulatory factors, was represented in a logical sequence in a pathway diagram built using yED graph editor software. The network was used with a Unique Network Identification Pipeline in the analysis of data from 18 publicly available transcriptomic data studies. This identified links between genes involved in asparagine metabolism in wheat roots under drought stress, wheat leaves under drought stress, and wheat leaves under conditions of sulfur and nitrogen deficiency. The network represents a powerful aid for interpreting the interactions not only between the genes in the pathway but also among enzymes, metabolites and smaller molecules. It provides a concise, clear understanding of the complexity of asparagine metabolism that could aid the interpretation of data relating to wider amino acid metabolism and other metabolic processes.
登录
查看更多内容
影响因子：
6.9
作者：
Avila-Ospina L;Marmagne A;Talbotec J;Krupinska K;Masclaux-Daubresse C
通讯作者：
Masclaux-Daubresse C
影响因子：
11.6
作者：
Coschigano, KT;Melo-Oliveira, R;Coruzzi, GM
通讯作者：
Coruzzi, GM
影响因子：
4.3
作者：
Borsani, O;Díaz, P;Monza, J
通讯作者：
Monza, J
影响因子：
6.1
作者：
Claus, Achim;Schreiter, Pat;Carle, Reinhold
通讯作者：
Carle, Reinhold
影响因子：
13.8
作者：
Baker, John M.;Hawkins, Nathaniel D.;Beale, Michael H.
通讯作者：
Beale, Michael H.