Use of Supplements of Multivitamins, Vitamin C, and Vitamin E in Relation to Mortality
Use of Supplements of Multivitamins, Vitamin C, and Vitamin E in Relation to Mortality
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DOI：
10.1093/aje/kwp167
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发表时间：
2009-08-15
影响因子：
5
通讯作者：
White, Emily
中科院分区：
文献类型：
--
作者：
Pocobelli, Gaia;Peters, Ulrike;White, Emily
在这项队列研究中，作者评估了在10年期间补充使用多种维生素、维生素C和维生素E与5年总死亡率、癌症死亡率和心血管疾病（CVD）死亡率之间的关系。参与者（n = 77,719）是华盛顿州50-76岁的居民，他们在2000-2002年完成了一份邮寄的自我管理问卷。采用Cox回归计算校正风险比和95%置信区间。复合维生素的使用与总死亡率无关。然而，维生素C和维生素E的使用与风险的小幅降低有关。在病因特异性分析中，使用复合维生素和使用维生素E与降低心血管疾病死亡率风险相关。10年平均每周服用6-7天复合维生素者与不服用者的风险比为0.84(95%可信区间：0.70,0.99)；10年平均每日服用维生素E剂量大于215毫克的人与不服用维生素E的人的风险比为0.72（95%可信区间：0.59,0.88）。相反，维生素C的使用与心血管疾病死亡率无关。复合维生素和维生素E的使用与癌症死亡率无关。我们观察到的一些关联很小，可能是由于补充剂使用者中更常见的未测量的健康行为。
In this cohort study, the authors evaluated how supplemental use of multivitamins, vitamin C, and vitamin E over a 10-year period was related to 5-year total mortality, cancer mortality, and cardiovascular disease (CVD) mortality. Participants (n = 77,719) were Washington State residents aged 50-76 years who completed a mailed self-administered questionnaire in 2000-2002. Adjusted hazard ratios and 95% confidence intervals were computed using Cox regression. Multivitamin use was not related to total mortality. However, vitamin C and vitamin E use were associated with small decreases in risk. In cause-specific analyses, use of multivitamins and use of vitamin E were associated with decreased risks of CVD mortality. The hazard ratio comparing persons who had a 10-year average frequency of multivitamin use of 6-7 days per week with nonusers was 0.84 (95% confidence interval: 0.70, 0.99); and the hazard ratio comparing persons who had a 10-year average daily dose of vitamin E greater than 215 mg with nonusers was 0.72 (95% confidence interval: 0.59, 0.88). In contrast, vitamin C use was not associated with CVD mortality. Multivitamin and vitamin E use were not associated with cancer mortality. Some of the associations we observed were small and may have been due to unmeasured healthy behaviors that were more common in supplement users.