Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax notoginseng extract
Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax notoginseng extract
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DOI：
10.1142/s0192415x0100054x
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发表时间：
2001-01-01
影响因子：
5.7
通讯作者：
Ou, YH
中科院分区：
文献类型：
--
作者：
Chen, FD;Wu, MC;Ou, YH
本研究的目的是研究三七提取物(PNE)和三七总皂苷(Rb1)对小鼠实验性肿瘤(KHT肉瘤)放射反应的增敏作用，并与对正常组织(骨髓)的任何作用进行比较。0.1-100 mg/kg的PNE可提高肿瘤的放射敏感性。10 mg/kg时致敏效果最好，注射后30min致敏效果最好。较高剂量对骨髓干细胞有毒性。同样，在0.001到1 mg/kg的浓度下，RBL也产生了肿瘤放射敏感性的增加，在1 mg/kg时效果最好。在这种情况下，较高剂量对骨髓干细胞没有毒性。放射增敏系数计算为D-0(放射敏感性参数)的比率，这些比率对肿瘤非常重要，对于所用剂量的两种化合物非常相似，即1.18-1.19。对骨髓干细胞无明显影响(两种化合物的致敏因子均为0.99+/-0.01)。对肿瘤的不同作用，以及放射增敏的程度，表明进一步纯化或合成的这种提取物不仅在血管相关疾病中有用，而且在癌症治疗中也有用。
The aim of the present study was to investigate any sensitization effect of the Panax notoginseng extract (PNE) and the purified Saponin (Rb1) on the radiation response of an experimental tumor (KHT sarcoma) in mice, in comparison with any effects on a normal tissue (bone marrow). PNE at a concentration of 0.1-100 mg/kg produced an increase in tumor radiosensitivity. The sensitization effect was maximal at 10 mg/kg and at 30 minutes after injection. Higher doses were toxic to the bone marrow stem cells. Similarly Rbl at a concentration 0.001 to I mg/kg also produced an increase in tumor radiosensitivity, with maximum effect at I mg/kg. Higher doses were not toxic to the bone marrow stem cells in this case. Radiosensitization factors were calculated as ratios of D-0 (the radiosensitivity parameter), and these were highly significant for the tumor and very similar for both compounds at the doses used, namely 1.18-1.19. There was no significant effect for bone marrow stem cells (sensitization factors of 0.99 +/- 0.01 for both compounds). The differential effect on tumor, and the magnitude of the radiosensitization, suggest that further purified or synthetic versions of this extract may be useful not only in vascular-related diseases but also in cancer therapy.