Apolipoprotein E in schizophrenia:: A French association study and meta-analysis
Apolipoprotein E in schizophrenia:: A French association study and meta-analysis
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DOI：
10.1002/ajmg.b.20007
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发表时间：
2003-05-15
影响因子：
2.8
通讯作者：
Leboyer, M
中科院分区：
文献类型：
--
作者：
Schürhoff, F;Krebs, MO;Leboyer, M
精神分裂症是复杂的遗传性疾病，可能涉及多个影响较小的基因。载脂蛋白 E (ApoE) 基因变异与大脑功能改变和阿尔茨海默病 (AD) 风险增加有关。然而，关于精神分裂症的研究结果却相互矛盾。我们比较了 114 名法国白人精神分裂症患者和 91 名正常对照者的 ApoE 基因型。两组之间没有观察到 ApoE 等位基因或基因型频率的差异。然而，我们观察到男性精神分裂症患者与 ApoE epsilon2epsilon3 基因型之间可能存在关联。此外，对所有已发表的 ApoE 和精神分裂症病例对照研究的荟萃分析并不支持 ApoE 基因变异在整个精神分裂症中的主要作用。然而，ApoE 可能与特定形式的精神分裂症有关。 (C) 2003 Wiley-Liss, Inc.
Schizophrenic disorders are complex genetic disorders that may involve multiple genes of small effect. Apolipoprotein E (ApoE) gene variants are associated with alterations in brain function and an increased risk of Alzheimer's disease (AD). However, conflicting results have been reported in schizophrenia. We compared the ApoE genotypes of 114 French Caucasian schizophrenic patients and 91 normal controls. No differences in ApoE allele or genotype frequencies were observed between the two groups. However, we observed a possible association between male schizophrenic patients and the ApoE epsilon2epsilon3 genotype. In addition, a meta-analysis of all published case-control studies on ApoE and schizophrenia did not support a major role for ApoE gene variants in schizophrenia as a whole. However, ApoE may be associated with particular forms of schizophrenia. (C) 2003 Wiley-Liss, Inc.