Cortical information flow during flexible sensorimotor decisions.
Cortical information flow during flexible sensorimotor decisions.
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DOI：
10.1126/science.aab0551
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发表时间：
2015-06-19
期刊：
影响因子：
--
通讯作者：
Miller EK
中科院分区：
文献类型：
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作者：
Siegel M;Buschman TJ;Miller EK
在灵活的行为过程中，多个大脑区域对感官输入、当前任务和选择进行编码。目前还不清楚这些信号是如何演变的。我们同时记录神经元活动从六个皮质区域（MT，V4，IT，LIP，PFC和FEF）的猴子报告的颜色或运动的刺激。在短暂的自下而上的扫描之后，有一个自上而下的持续任务信息流从额顶叶到视觉皮层。感觉信息从视觉传递到顶叶和前额叶皮层。选择信号在额顶区同时发展，并传递到FEF和感觉皮层。这表明，灵活的感觉运动选择出现在额顶叶网络从相反的感觉和任务信息流的整合。
During flexible behavior, multiple brain regions encode sensory inputs, the current task, and choices. It remains unclear how these signals evolve. We simultaneously recorded neuronal activity from six cortical regions (MT, V4, IT, LIP, PFC and FEF) of monkeys reporting the color or motion of stimuli. Following a transient bottom-up sweep, there was a top-down flow of sustained task information from frontoparietal to visual cortex. Sensory information flowed from visual to parietal and prefrontal cortex. Choice signals developed simultaneously in frontoparietal regions and travelled to FEF and sensory cortex. This suggests that flexible sensorimotor choices emerge in a frontoparietal network from the integration of opposite flows of sensory and task information.