Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection
Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection
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DOI：
10.1016/j.trim.2004.10.006
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发表时间：
2004-12-01
影响因子：
1.5
通讯作者：
Suciu-Foca, N
中科院分区：
文献类型：
--
作者：
Liu, JW;Liu, ZR;Suciu-Foca, N
人类CD8(+) FOXP3(+) T抑制细胞（T- s）在树突状细胞和内皮细胞上诱导抑制受体、免疫球蛋白样转录物（ILT） 3和ILT4的表达，使它们对同种异体T细胞产生耐受性。我们在同种异体心脏移植大鼠模型中证明了CD8(+) T-S的重要性。ACI受者通过多次输入Lewis心脏供者的uvb照射血液诱导耐受性。耐受性ACI大鼠的CD8(+) T细胞表达FOXP3，将耐受性转移到初始次级宿主，并诱导Lewis树突状细胞（DC）和心脏内皮细胞（EC）中抑制受体配对免疫球蛋白样受体(PIR)-B， ILT4同源物的上调。当长期存活的带有PIR-B+ EC的Lewis心脏同种异体移植从原发性移植到继发性ACI受体时，它们没有引起排斥反应。这项研究的重点是需要开发直接作用于移植物EC的药物，以实现耐受性。(C) 2004 Elsevier B.V.版权所有
Human CD8(+) FOXP3(+) T suppressor cells (T-S) were previously shown to induce the expression of the inhibitory receptors, Immunoglobulin-like transcript (ILT) 3 and ILT4 on dendritic and endothelial cells, rendering them tolerogenic to allogeneic T cells. We have demonstrated the importance of CD8(+) T-S in a rat model of heart allo-transplantation. Tolerance was induced in ACI recipients by multiple transfusions of UVB-irradiated blood from Lewis heart donors. CD8(+) T cells from tolerant ACI rats expressed FOXP3, transferred tolerance to naive secondary hosts and induced the upregulation of the inhibitory receptor, paired immunoglobulin-like receptor (PIR)-B, an ILT4 orthologue, in Lewis dendritic cells (DC) and heart endothelial cells (EC). When long-term surviving Lewis heart allografts with PIR-B+ EC were retransplanted from a primary to a secondary ACI recipient they did not elicit rejection. This study focuses attention on the need to develop agents that act directly on graft EC in order to achieve tolerance. (C) 2004 Elsevier B.V. All rights reserved.