FUNCTIONAL-ORGANIZATION OF TRIGEMINAL SUBNUCLEUS INTERPOLARIS - NOCICEPTIVE AND INNOCUOUS AFFERENT INPUTS, PROJECTIONS TO THALAMUS, CEREBELLUM, AND SPINAL-CORD, AND DESCENDING MODULATION FROM PERIAQUEDUCTAL GRAY
FUNCTIONAL-ORGANIZATION OF TRIGEMINAL SUBNUCLEUS INTERPOLARIS - NOCICEPTIVE AND INNOCUOUS AFFERENT INPUTS, PROJECTIONS TO THALAMUS, CEREBELLUM, AND SPINAL-CORD, AND DESCENDING MODULATION FROM PERIAQUEDUCTAL GRAY
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DOI：
10.1152/jn.1984.51.5.890
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
SESSLE, BJ
中科院分区：
文献类型：
--
作者：
HAYASHI, H;SUMINO, R;SESSLE, BJ
鉴于三叉神经脊束核内亚核神经元的组织、传入输入和投射部位的不确定性，在氯醛糖麻醉的成年猫中，观察了亚核内及邻近亚核222个神经元的电生理学特征。本研究证明猫内V亚核是一种有组织的躯体组织结构，其主要神经元类型为机械感受野受限的LTM神经元。皮肤、粘膜、肌肉和牙髓传入的汇聚量相当大。此外，内侧核存在伤害性神经元，可能参与V伤害性机制。电生理学证据表明，所有3类内插神经元都直接投射到丘脑、小脑或脊髓，它们对非伤害性刺激和伤害性刺激的反应均可被PAG的下行影响所调节。
In view of continuing uncertainties concerning the organization, afferent inputs and projection sites of neurons in the subnucleus interpolaris of the trigeminal (V) spinal tract nucleus, the characteristics of 222 single neurons in and adjacent to the subnucleus were examined electrophysiologically in adult cats anesthetized with chloralose. This study demonstrated that the V subnucleus interpolaris of the cat is a somatotopically organized structure in which the major neuron type is the LTM neuron that has a restricted mechanoreceptive field. A considerable amount of convergence of cutaneous, mucosal, muscle and tooth pulp afferents occurs. Moreover, nociceptive neurons exist in the interpolaris that may contribute to V nociceptive mechanisms. Electrophysiological evidence that many interpolaris neurons of all 3 classes project directly to thalamus, cerebellum or spinal cord, and that their responsiveness to nonnoxious as well as to noxious stimuli can be modulated by descending influences from PAG was provided.