Primary role of volume expansion in stimulation of rectal gland function.
Primary role of volume expansion in stimulation of rectal gland function.
复制标题
体积扩张在刺激直肠腺功能中的主要作用。
DOI：
10.1152/ajpregu.1985.248.5.r638
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Epstein,FH
中科院分区：
文献类型：
--
作者：
Solomon,R;Taylor,M;Sheth,S;Silva,P;Epstein,FH
血管内注入不同渗透浓度和钠浓度的盐溶液可刺激鲨鱼体内直肠腺的氯离子分泌。在交叉灌流和去神经的直肠腺中，注入少量的高渗盐溶液可以提高供体鱼的血浆渗透压，但不会增加血浆容量。在这种情况下，直肠腺的氯化物分泌不受刺激。随后注入等渗鲨鱼林格溶液使血浆容量增加50%，降低血浆渗透压，并使氯化物分泌增加四倍，腺体内血管阻力减少三倍。血管扩张和分泌反应也伴随着低张鲨鱼林格溶液的输注。这些数据进一步支持了鲨鱼直肠腺参与血管内容量调节而不是渗透压调节的假设。
Chloride secretion by the in vivo rectal gland of the shark is stimulated by the intravascular infusion of salt solutions of varying osmolar and sodium concentration. In a cross-perfused and denervated rectal gland, the infusion of a small amount of a hypertonic salt solution raises plasma osmolality but does not increase plasma volume in the donor fish. Under these conditions, rectal gland chloride secretion is not stimulated. A subsequent infusion of isotonic shark Ringer solution increases plasma volume 50%, decreases plasma osmolality, and produces a fourfold increase in chloride secretion and a threefold decrease in vascular resistance within the gland. Both the vasodilatory and secretory responses also follow the infusion of a hypotonic shark Ringer solution. The data further support the hypothesis that the rectal gland of the shark is involved in the regulation of intravascular volume rather than in osmoregulation.