The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis.
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis.
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DOI：
10.7150/thno.50683
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发表时间：
2021
期刊：
影响因子：
12.4
通讯作者：
Heymann D
中科院分区：
文献类型：
--
作者：
Muñoz-Garcia J;Cochonneau D;Télétchéa S;Moranton E;Lanoe D;Brion R;Lézot F;Heymann MF;Heymann D
巨噬细胞是控制组织动态平衡的特殊细胞。它们包括非驻留和组织驻留的巨噬细胞群体，其特征是表达特定的细胞表面标记和分泌具有广泛生物学功能的分子。巨噬细胞的分化和极化依赖于特定的生长因子及其受体。巨噬细胞集落刺激因子(CSF-1)和白细胞介素34(IL-34)，也被称为“双胞胎”细胞因子，是这一调节格局的一部分。CSF-1和IL-34共享一个共同的受体，即巨噬细胞集落刺激因子受体(CSF-1R)，它被两种因子以相似的方式激活，并启动相同的信号通路。然而，有一些离散的差异激活导致特定的活动。在这篇综述中，我们讨论了双细胞因子在巨噬细胞分化中的作用，从它们与CSF-1R的相互作用和信号通路的激活，到它们在非驻留和组织驻留的巨噬细胞极化中的作用。将特别关注IL-34，它在病理生理环境中的参与，以及它作为巨噬细胞治疗的治疗靶点的潜力。
Macrophages are specialized cells that control tissue homeostasis. They include non-resident and tissue-resident macrophage populations which are characterized by the expression of particular cell surface markers and the secretion of molecules with a wide range of biological functions. The differentiation and polarization of macrophages relies on specific growth factors and their receptors. Macrophage-colony stimulating factor (CSF-1) and interleukine-34 (IL-34), also known as “twin” cytokines, are part of this regluatory landscape. CSF-1 and IL-34 share a common receptor, the macrophage-colony stimulating factor receptor (CSF-1R), which is activated in a similar way by both factors and turns on identical signaling pathways. However, there is some discrete differential activation leading to specific activities. In this review, we disscuss recent progress in understanding of the role of the twin cytokines in macrophage differentiation, from their interaction with CSF-1R and the activation of signaling pathways, to their implication in macrophage polarization of non-resident and tissue-resident macrophages. A special focus on IL-34, its involvement in pathophsyiological contexts, and its potential as a theranostic target for macrophage therapy will be proposed.